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PMID: 8692992 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Dimorphism and haploid fruiting in Cryptococcus neoformans: association with the alpha-mating type.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 14 ·1996-07-09 ·Pages 7327-31

Wickes BL, Mayorga ME, Edman U, Edman JC

Abstract

Cryptococcus neoformans is a major opportunistic fungal pathogen in AIDS and other immunosuppressed patients. We have shown that wild-type haploid C. neoformans can develop an extensive hyphal phase under appropriate conditions. Hyphae produced under these conditions are monokaryotic, possess unfused clamp connections, and develop basidia with viable basidiospores. The ability to undergo this transition is determined by the presence of the alpha-mating type locus and is independent of serotype. The association of the hyphal phase with the alpha-mating type may explain the preponderance of this mating type in the environment and the nature of the infectious propagule of C. neoformans.

MeSH Terms
AIDS-Related Opportunistic Infections/microbiology Crosses, Genetic Cryptococcosis Cryptococcus neoformans/genetics,pathogenicity,physiology Haploidy Humans Mating Factor Peptide Biosynthesis Peptides Phenotype Pheromones Spores, Fungal
Chemicals
Peptides Pheromones Mating Factor
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wickes B L
Department of Laboratory Medicine, University of California, San Francisco, USA.
Mayorga M E
Edman U
Edman J C
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.14.7327
Published
1996-07-09
Pages
7327-31
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC38983
Subset
IM
Grants
NIAID NIH HHS · R01 AI 29312 · United States
External Links
PubMed source DOI: 10.1073/pnas.93.14.7327 PMC Full Text View journal details
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