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PMID: 8696010 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.

Natural immunity ·Vol. 14 ·No. 4 ·1995-04-00 ·Pages 209-15

Johnson LL, Sayles PC

Abstract

That strong cytolytic activity of natural killer (NK) cells is neither necessary nor sufficient for defense against acute Toxoplasma gondii infection is demonstrated. T. gondii-infected anti-interferon (IFN)-gamma-treated mice and IFN-gamma gene knockout mice died despite good induction of NK activity, while infected beige mice, deficient in NK cytolytic activity, survived.

MeSH Terms

Animals Cytotoxicity, Immunologic/immunology Immunity, Innate Interferon-gamma/immunology Killer Cells, Natural/immunology Mice Mice, Inbred C57BL Toxoplasmosis, Animal/immunology

Chemicals

Interferon-gamma

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Johnson L L

Trudeau Institute, Inc., Saranac Lake, N.Y., USA.

Sayles P C

Article Info

Journal

Natural immunity

Abbr.

Nat Immun

ISSN

1018-8916

Published

1995-04-00

Pages

209-15

Language

English

Region

Switzerland

NLM ID

9206126

Subset

Grants

NIAID NIH HHS · AI37090 · United States

External Links

PubMed source

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Strong cytolytic activity of natural killer cells is neither necessary nor sufficient for preimmune resistance to Toxoplasma gondii infection.

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