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PMID: 8696977 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Recent developments in DNA topoisomerase II structure and mechanism.

Current opinion in structural biology ·Vol. 6 ·No. 1 ·1996-02-00 ·Pages 84-90

Berger JM, Wang JC

Abstract

Type II DNA topoisomerases are enzymes that are capable of transporting one duplex DNA through another. Recent experimental results, including the structure of a fragment of yeast topoisomerase II, have provided new insights into the mechanism of the strand passage reaction. Other results have begun to define the role of ATP in the catalytic cycle and illuminate how DNA breaks mediated by topoisomerase II can occur.

MeSH Terms

Adenosine Triphosphate/metabolism Animals Bacterial Proteins/chemistry,metabolism Binding Sites Catalysis Crystallography, X-Ray DNA/metabolism DNA Gyrase DNA Topoisomerases, Type II/chemistry,metabolism DNA, Bacterial/metabolism DNA, Fungal/metabolism Fungal Proteins/chemistry,metabolism Models, Molecular Protein Binding Saccharomyces cerevisiae/enzymology Structure-Activity Relationship

Chemicals

Bacterial Proteins DNA, Bacterial DNA, Fungal Fungal Proteins Adenosine Triphosphate DNA DNA Gyrase DNA Topoisomerases, Type II

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Berger J M

Whitehead Institute for Biomedical Research, Cambridge, MA 02142, USA.

Wang J C

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/s0959-440x(96)80099-6

Published

1996-02-00

Pages

84-90

Language

English

Region

England

NLM ID

9107784

Subset

External Links

PubMed source DOI: 10.1016/s0959-440x(96)80099-6 View journal details

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