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PMID: 869918 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Kinetic studies on the enzymes conjugating bile acids with taurine and glycine in bovine liver.

The Biochemical journal ·Vol. 163 ·No. 1 ·1977-04-01 ·Pages 181-3

Vessey DA, Crissey MH, Zakim D

Abstract

Synthesis of glyco- or tauro-cholate from choloyl-CoA and the respective amino acid is shown to be catalysed by the soluble fraction of liver cells. Kinetic evidence supports the conclusion that there are separate enzymes for the synthesis of glycocholate and taurocholate. The kinetic parameters of these enzymes were determined.

MeSH Terms
Animals Cattle Cholic Acids/biosynthesis Coenzyme A Ligases/metabolism Glycine/metabolism Glycocholic Acid/biosynthesis In Vitro Techniques Kinetics Liver/enzymology Taurine/metabolism Taurocholic Acid/biosynthesis
Chemicals
Cholic Acids Taurine Taurocholic Acid Coenzyme A Ligases Glycocholic Acid Glycine
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Vessey D A
Crissey M H
Zakim D
References (6)
6 references, click to expand
  1. Enzymatic synthesis of cholyl coA and taurocholic acid.
    Science. 1956 Mar 2;123(3192):377-8 PMID: 13298695
  2. The enzymic synthesis of taurocholic acid: a qualitative study.
    Biochem J. 1956 Mar;62(3):433-6 PMID: 13303992
  3. Species differences in the conjugation of free bile acids with taurine and glycine.
    Biochem J. 1956 Jul;63(3):507-13 PMID: 13341913
  4. Enzymic activation of cholic acid involving coenzyme A.
    Biochim Biophys Acta. 1955 Jul;17(3):440-1 PMID: 13239702
  5. Synthesis of coenzyme A esters of some bile acids.
    Steroids. 1968 Nov;12(5):571-6 PMID: 5723657
  6. The synthesis of taurocholic and glycocholic acids by preparations of human liver. I. Distribution of activity between subcellular fractions.
    Biochim Biophys Acta. 1967 Jun 13;141(1):144-54 PMID: 6051574
Article Info
Journal
The Biochemical journal
Abbr.
Biochem J
ISSN
0264-6021
DOI
10.1042/bj1630181
Published
1977-04-01
Pages
181-3
Language
English
Region
England
NLM ID
2984726R
PMCID
PMC1164677
Subset
IM
External Links
PubMed source DOI: 10.1042/bj1630181 PMC Full Text View journal details
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