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PMID: 8709292 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Characterization of tumor cell lines derived from murine gammaherpesvirus-68-infected mice.

Journal of virology ·Vol. 70 ·No. 9 ·1996-09-00 ·Pages 6516-8

Usherwood EJ, Stewart JP, Nash AA

Abstract

Cell lines were derived from mice with murine gammaherpesvirus-68 (MHV-68)-associated lymphoproliferative disease. Four were of an ambiguous phenotype and were MHV-68 negative. One, S11, was a B lymphocyte that contained MHV-68 genomes in both linear and episomal forms and released virus. The line was clonable and grew into tumors in nude mice. This is the first naturally occurring MHV-68-positive B-cell line to be generated, and it will be an invaluable tool for the study of MHV-68 latency.

MeSH Terms
Acyclovir/pharmacology Animals Antiviral Agents/pharmacology Culture Techniques/methods Gammaherpesvirinae/drug effects,physiology Herpesviridae Infections Lymphoma/immunology,pathology,virology Mice Mice, Nude Neoplasm Transplantation Phenotype Tumor Cells, Cultured Tumor Virus Infections
Chemicals
Antiviral Agents Acyclovir
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Usherwood E J
Department of Veterinary Pathology, University of Edinburgh, Summerhall, United Kingdom. [email protected]
Stewart J P
Nash A A
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.70.9.6516-6518.1996
Email
[email protected]
Published
1996-09-00
Pages
6516-8
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC190690
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.70.9.6516-6518.1996 PMC Full Text View journal details
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