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PMID: 872122 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.

Cancer research ·Vol. 37 ·No. 8 Pt 2 ·1977-08-00 ·Pages 2930-6

Squire RA, Sporn MB, Brown CC, Smith JM, Wenk ML, Springer S

Abstract

An objective system for histopathological and statistical evaluation of rat bladder lesions induced by the carcinogen, N-methyl-N-nitrosourea, is described. This system has been used to measure the inhibitory effects of 13-cis-retinoic acid on the development of bladder cancer in female Wistar/Lewis rats. 13-cis-Retinoic acid caused significant inhibition of development of both preneoplastic and neoplastic lesions in bladder epithelium.

MeSH Terms

Animals Epithelium/pathology Female Methylnitrosourea Neoplasms, Experimental/chemically induced,pathology,prevention & control Precancerous Conditions/chemically induced,pathology,prevention & control Rats Statistics as Topic Tretinoin/pharmacology Urinary Bladder Neoplasms/chemically induced,pathology,prevention & control Vitamin A/analogs & derivatives

Chemicals

Vitamin A Tretinoin Methylnitrosourea

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Squire R A

Sporn M B

Brown C C

Smith J M

Wenk M L

Springer S

Article Info

Journal

Cancer research

Abbr.

Cancer Res

ISSN

0008-5472

Published

1977-08-00

Pages

2930-6

Language

English

Region

United States

NLM ID

2984705R

Subset

External Links

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Histopathological evaluation of the inhibition of rat bladder carcinogenesis by 13-cis-retinoic acid.

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