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PMID: 8725944 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S. Review

The molecular basis of somatic hypermutation of immunoglobulin genes.

Current opinion in immunology ·Vol. 8 ·No. 2 ·1996-04-00 ·Pages 206-14

Storb U

Abstract

Somatic hypermutation amplifies the variable region repertoire of immunoglobulin genes. Recent experimental evidence has thrown light on various molecular models of somatic hypermutation. A link between somatic hypermutation and transcription coupled DNA repair is shaping up.

MeSH Terms
Animals Genes, Immunoglobulin/genetics Models, Genetic Mutation/immunology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Storb U
Department of Molecular Genetics and Cell Biology, University of Chicago, IL 60637, USA. [email protected]
Article Info
Journal
Current opinion in immunology
Abbr.
Curr Opin Immunol
ISSN
0952-7915
DOI
10.1016/s0952-7915(96)80059-8
Email
[email protected]
Published
1996-04-00
Pages
206-14
Language
English
Region
England
NLM ID
8900118
Subset
IM
Grants
NIGMS NIH HHS · GM38649 · United States
External Links
PubMed source DOI: 10.1016/s0952-7915(96)80059-8 View journal details
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