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PMID: 8727911 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Antagonistic effect of oral bacteria towards Treponema denticola.

Journal of clinical microbiology ·Vol. 34 ·No. 5 ·1996-05-00 ·Pages 1249-52

Grenier D

Abstract

This study was designed to isolate oral bacteria exhibiting antagonism towards Treponema denticola and to characterize the inhibitory activity. Eleven bacterial isolates obtained from subgingival sites and identified as either Staphylococcus aureus or Streptococcus mutans were found to inhibit the growth of T. denticola. When the activity spectra of these isolates were analyzed, two additional periodontopathogens (Porphyromonas gingivalis and Prevotella intermedia) were found to be affected, whereas most gram-positive bacteria were not. Strains of S. aureus produce a bacteriocin-like inhibitory substance (heat stable and protease sensitive), whereas the inhibitory effect of S. mutans appears to be related to the production of lactic acid. The negative interactions reported in this paper may govern population shifts observed in subgingival sites.

MeSH Terms
Bacteria/isolation & purification Bacterial Physiological Phenomena Bacteriocins/biosynthesis Ecosystem Gram-Positive Bacteria/isolation & purification,physiology Humans Lactates/biosynthesis Lactic Acid Mouth/microbiology Porphyromonas gingivalis/isolation & purification,pathogenicity,physiology Prevotella/isolation & purification,pathogenicity,physiology Staphylococcus aureus/isolation & purification,physiology Streptococcus mutans/isolation & purification,physiology Treponema/growth & development,pathogenicity
Chemicals
Bacteriocins Lactates Lactic Acid
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Grenier D
Groupe de Recherche en Ecologie Buccale, Faculté de Médecine Dentaire, Université Laval, Québec, Canada. [email protected]
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Article Info
Journal
Journal of clinical microbiology
Abbr.
J Clin Microbiol
ISSN
0095-1137
DOI
10.1128/jcm.34.5.1249-1252.1996
Email
[email protected]
Published
1996-05-00
Pages
1249-52
Language
English
Region
United States
NLM ID
7505564
PMCID
PMC228990
Subset
IM
External Links
PubMed source DOI: 10.1128/jcm.34.5.1249-1252.1996 PMC Full Text View journal details
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