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PMID: 8746403 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Pyramidal cell-to-inhibitory cell spike transduction explicable by active dendritic conductances in inhibitory cell.

Journal of computational neuroscience ·Vol. 2 ·No. 4 ·1995-12-00 ·Pages 291-8

Traub RD, Miles R

Abstract

In the guinea-pig hippocampal CA3 region, the synaptic connection from pyramidal neurons to stratum pyramidale inhibitory neurons is remarkable. Anatomically, the connection usually consists of a single release site on an interneuronal dendrite, sometimes 200 microns or more from the soma. Nevertheless, the connection is physiologically powerful, in that a single presynaptic action potential can evoke, with probability 0.1 to 0.6, a postsynaptic action potential with latency 2 to 6 ms. We construct a model interneuron and show that the anatomical and physiological observations can be reconciled if the interneuron dendrites are electrically excitable. Excitable dendrites could also account for depolarization-induced amplification of the pyramidal cell-interneuron EPSP in the voltage range subthreshold for spike generation.

MeSH Terms
Action Potentials Animals Axons/physiology Cell Communication Dendrites/physiology Electric Conductivity Evoked Potentials Guinea Pigs Hippocampus/physiology In Vitro Techniques Models, Neurological Neurons/physiology Pyramidal Cells/physiology Signal Transduction Synapses/physiology Time Factors
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Traub R D
IBM Research Division, T.J. Watson Research Center, Yorktown Heights, NY 10598, USA.
Miles R
References (42)
42 references, click to expand
  1. Membrane properties and synaptic responses of interneurons located near the stratum lacunosum-moleculare/radiatum border of area CA1 in whole-cell recordings from rat hippocampal slices.
    J Neurophysiol. 1994 Jun;71(6):2217-35 PMID: 7931512
  2. Intradendritic recordings from hippocampal neurons.
    Proc Natl Acad Sci U S A. 1979 Feb;76(2):986-90 PMID: 284423
  3. Excitatory synaptic responses mediated by GABAA receptors in the hippocampus.
    Science. 1991 Sep 20;253(5026):1420-3 PMID: 1654594
  4. Activity-induced elevations of intracellular calcium concentration in pyramidal and nonpyramidal cells of the CA3 region of rat hippocampal slice cultures.
    J Neurophysiol. 1992 Sep;68(3):961-3 PMID: 1432060
  5. Unitary inhibitory synaptic potentials in the guinea-pig hippocampus in vitro.
    J Physiol. 1984 Nov;356:97-113 PMID: 6097680
  6. Enhancement of synaptic transmission by dendritic potentials in chromatolysed motoneurones of the cat.
    J Physiol. 1970 Nov;210(4):807-21 PMID: 4322766
  7. Synaptic excitation of inhibitory cells by single CA3 hippocampal pyramidal cells of the guinea-pig in vitro.
    J Physiol. 1990 Sep;428:61-77 PMID: 2231426
  8. Precision and variability in postsynaptic target selection of inhibitory cells in the hippocampal CA3 region.
    Eur J Neurosci. 1993 Dec 1;5(12):1729-51 PMID: 8124523
  9. Differential subcellular localization of the RI and RII Na+ channel subtypes in central neurons.
    Neuron. 1989 Dec;3(6):695-704 PMID: 2561976
  10. Apical dendrites of the neocortex: correlation between sodium- and calcium-dependent spiking and pyramidal cell morphology.
    J Neurosci. 1993 Dec;13(12):5301-11 PMID: 8254376
  11. Electrophysiological properties of dendrites and somata in alligator Purkinje cells.
    J Neurophysiol. 1971 Jul;34(4):532-51 PMID: 4329778
  12. Physiological properties of anatomically identified axo-axonic cells in the rat hippocampus.
    J Neurophysiol. 1994 Apr;71(4):1289-307 PMID: 8035215
  13. Synaptic and intrinsic conductances shape picrotoxin-induced synchronized after-discharges in the guinea-pig hippocampal slice.
    J Physiol. 1993 Feb;461:525-47 PMID: 8350274
  14. Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation.
    Nature. 1995 Feb 16;373(6515):612-5 PMID: 7854418
  15. Kinetic properties of NMDA receptor-mediated synaptic currents in rat hippocampal pyramidal cells versus interneurones.
    J Physiol. 1993 Jun;465:223-44 PMID: 7901401
  16. Enhanced NMDA conductance can account for epileptiform activity induced by low Mg2+ in the rat hippocampal slice.
    J Physiol. 1994 Aug 1;478 Pt 3:379-93 PMID: 7965853
  17. Alterations of synaptic action in chromatolysed motoneurones of the cat.
    J Physiol. 1970 Nov;210(4):823-38 PMID: 4322767
  18. Inhibitory control of local excitatory circuits in the guinea-pig hippocampus.
    J Physiol. 1987 Jul;388:611-29 PMID: 3656200
  19. Active propagation of somatic action potentials into neocortical pyramidal cell dendrites.
    Nature. 1994 Jan 6;367(6458):69-72 PMID: 8107777
  20. Phase relations of hippocampal projection cells and interneurons to theta activity in the anesthetized rat.
    Brain Res. 1983 May 5;266(2):334-9 PMID: 6191827
  21. Electrophysiological properties of in vitro Purkinje cell dendrites in mammalian cerebellar slices.
    J Physiol. 1980 Aug;305:197-213 PMID: 7441553
  22. Postsynaptic potentials mediated by excitatory and inhibitory amino acids in interneurons of stratum pyramidale of the CA1 region of rat hippocampal slices in vitro.
    J Neurophysiol. 1991 Nov;66(5):1441-54 PMID: 1684988
  23. Properties of spontaneous and evoked synaptic activities of thalamic ventrobasal neurons.
    J Neurophysiol. 1967 Mar;30(2):360-81 PMID: 6045200
  24. Complete axon arborization of a single CA3 pyramidal cell in the rat hippocampus, and its relationship with postsynaptic parvalbumin-containing interneurons.
    Eur J Neurosci. 1993 Dec 1;5(12):1719-28 PMID: 8124522
  25. Electrophysiological properties of cat reticular thalamic neurones in vivo.
    J Physiol. 1993 Oct;470:273-94 PMID: 8308730
  26. Different glutamate receptor channels mediate fast excitatory synaptic currents in inhibitory and excitatory cortical neurons.
    Neuron. 1993 Dec;11(6):1083-91 PMID: 7506044
  27. Voltage dependence of NMDA-activated macroscopic conductances predicted by single-channel kinetics.
    J Neurosci. 1990 Sep;10(9):3178-82 PMID: 1697902
  28. ELECTROPHYSIOLOGY OF HIPPOCAMPAL NEURONS: IV. FAST PREPOTENTIALS.
    J Neurophysiol. 1961 May 1;24(3):272-85 PMID: 25286477
  29. A branching dendritic model of a rodent CA3 pyramidal neurone.
    J Physiol. 1994 Nov 15;481 ( Pt 1):79-95 PMID: 7853251
  30. A model of a CA3 hippocampal pyramidal neuron incorporating voltage-clamp data on intrinsic conductances.
    J Neurophysiol. 1991 Aug;66(2):635-50 PMID: 1663538
  31. Postsynaptic-GABAergic inhibition of non-pyramidal neurons in the guinea-pig hippocampus.
    Neuroscience. 1986 Sep;19(1):193-206 PMID: 3537840
  32. Properties of excitatory postsynaptic currents recorded in vitro from rat hippocampal interneurones.
    J Physiol. 1990 Nov;430:605-16 PMID: 1982315
  33. Hippocampal pyramidal cells excite inhibitory neurons through a single release site.
    Nature. 1993 Dec 16;366(6456):683-7 PMID: 8259211
  34. Local circuit synaptic interactions in hippocampal brain slices.
    J Neurosci. 1981 Mar;1(3):318-22 PMID: 7264721
  35. Electrotonic profiles of interneurons in stratum pyramidale of the CA1 region of rat hippocampus.
    J Neurophysiol. 1994 May;71(5):1948-58 PMID: 8064358
  36. Localization of P-type calcium channels in the central nervous system.
    Proc Natl Acad Sci U S A. 1991 Aug 15;88(16):7076-80 PMID: 1651493
  37. Developmental changes in Na+ conductances in rat neocortical neurons: appearance of a slowly inactivating component.
    J Neurophysiol. 1988 Mar;59(3):778-95 PMID: 2452862
  38. Electrophysiology of isolated hippocampal pyramidal dendrites.
    J Neurosci. 1982 Nov;2(11):1614-22 PMID: 6292377
  39. Properties of persistent sodium conductance and calcium conductance of layer V neurons from cat sensorimotor cortex in vitro.
    J Neurophysiol. 1985 Jan;53(1):153-70 PMID: 2579215
  40. Tetanic stimuli induce a short-term enhancement of recurrent inhibition in the CA3 region of guinea-pig hippocampus in vitro.
    J Physiol. 1991 Nov;443:669-82 PMID: 1688027
  41. Excitatory synaptic connections onto rat hippocampal inhibitory cells may involve a single transmitter release site.
    J Physiol. 1994 Dec 1;481 ( Pt 2):395-405 PMID: 7738832
  42. Heterogeneity of synaptic glutamate receptors on CA3 stratum radiatum interneurones of rat hippocampus.
    J Physiol. 1993 Mar;462:373-92 PMID: 8101227
Article Info
Journal
Journal of computational neuroscience
Abbr.
J Comput Neurosci
ISSN
0929-5313
DOI
10.1007/BF00961441
Published
1995-12-00
Pages
291-8
Language
English
Region
United States
NLM ID
9439510
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00961441 View journal details
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