Regulatory GTPases.

Current opinion in structural biology ·Vol. 5 ·No. 6 ·1995-12-00 ·Pages 810-7

Hilgenfeld R

Abstract

The past year has witnessed a tremendous increase in our understanding of the structures and interactions of the GTPases. The highlights include crystal structures of G alpha subunits, as well as the first complex between a GTPase (Rap1A) and an effector molecule (c-Raf1 Ras-binding domain). In the field of elongation factors (EFs), three very important structures have been determined: EF-G, the ternary complex of EF-Tu.GTP with aminoacyl-tRNA, and the EF-Tu.EF-Ts complex.

MeSH Terms

Crystallography, X-Ray GTP Phosphohydrolase-Linked Elongation Factors/chemistry,metabolism GTP-Binding Proteins/chemistry,metabolism Guanosine Triphosphate/metabolism Hydrogen Bonding Models, Molecular Peptide Elongation Factor Tu/chemistry,metabolism Peptide Elongation Factors/chemistry,metabolism Protein Conformation Protein Serine-Threonine Kinases/chemistry Protein Structure, Secondary Proto-Oncogene Proteins/chemistry Proto-Oncogene Proteins c-raf RNA, Transfer/metabolism rap GTP-Binding Proteins ras Proteins/chemistry,metabolism

Chemicals

Peptide Elongation Factors Proto-Oncogene Proteins Guanosine Triphosphate RNA, Transfer Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-raf GTP Phosphohydrolase-Linked Elongation Factors GTP-Binding Proteins Peptide Elongation Factor Tu rap GTP-Binding Proteins ras Proteins

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Hilgenfeld R

Institute of Molecular Biotechnology, Jena, Germany.

Article Info

Journal

Current opinion in structural biology

Abbr.

Curr Opin Struct Biol

ISSN

0959-440X

DOI

10.1016/0959-440x(95)80015-8

Published

1995-12-00

Pages

810-7

Language

English

Region

England

NLM ID

9107784

Subset

External Links

PubMed source DOI: 10.1016/0959-440x(95)80015-8 View journal details

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