Home LiteratureArticle Details

PMID: 8765504 Published · ppublish English Journal Article

(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.

Journal of medicinal chemistry ·Vol. 39 ·No. 17 ·1996-08-16 ·Pages 3235-7

Cosford ND, Bleicher L, Herbaut A, McCallum JS, Vernier JM, Dawson H, Whitten JP, Adams P, Chavez-Noriega L, Correa LD, Crona JH, Mahaffy LS, Menzaghi F, Rao TS, Reid R, Sacaan AI, Santori E, Stauderman KA, Whelan K, Lloyd GK, McDonald IA

Abstract

暂无摘要

MeSH Terms

Animals Antiparkinson Agents/chemical synthesis,chemistry,pharmacology Cell Line Female Humans Kinetics Molecular Structure Neurons/physiology Oocytes/physiology Patch-Clamp Techniques Pyridines/chemical synthesis,chemistry,pharmacology Pyrrolidines/chemical synthesis,chemistry,pharmacology Receptors, Nicotinic/drug effects,physiology Recombinant Proteins/drug effects,metabolism Stereoisomerism Xenopus

Chemicals

Antiparkinson Agents Pyridines Pyrrolidines Receptors, Nicotinic Recombinant Proteins altinicline maleate

Authors & Affiliations

21 authors, click to expand affiliations / ORCID

Cosford N D

SIBIA Neurosciences Inc., La Jolla, California 92037, USA.

Bleicher L

Herbaut A

McCallum J S

Vernier J M

Dawson H

Whitten J P

Adams P

Chavez-Noriega L

Correa L D

Crona J H

Mahaffy L S

Menzaghi F

Rao T S

Reid R

Sacaan A I

Santori E

Stauderman K A

Whelan K

Lloyd G K

McDonald I A

Article Info

Journal

Journal of medicinal chemistry

Abbr.

J Med Chem

ISSN

0022-2623

DOI

10.1021/jm960328w

Published

1996-08-16

Pages

3235-7

Language

English

Region

United States

NLM ID

9716531

Subset

External Links

PubMed source DOI: 10.1021/jm960328w View journal details

Analysis Services

(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.

Contact

WeChat Official Account