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PMID: 87677 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Genetic marker for insulin-dependent diabetes mellitus.

Lancet (London, England) ·Vol. 1 ·No. 8128 ·1979-06-09 ·Pages 1208-10

Raum D, Alper CA, Stein R, Gabbay KH

Abstract

A rare genetic type (Bf F1) of properdin factor B is found in 22.6% of patients with insulin-dependent diabetes mellitus but in only 1.9% of the general population, yielding a relative risk of 15.0. This indicates that a genetic locus for insulin-dependent diabetes mellitus is very close on chromosome 6 to Bf, and that Bf F1 is a marker for nearly 1 out of 4 insulin-dependent diabetic patients.

MeSH Terms

Adult Alleles Child Chromosome Mapping Chromosomes, Human, 6-12 and X Complement Factor B/genetics Diabetes Mellitus/drug therapy,genetics,transmission Diabetes Mellitus, Type 1/genetics Diseases in Twins Enzyme Precursors/genetics Female Humans Insulin/therapeutic use Male Pedigree Pregnancy Twins, Monozygotic

Chemicals

Enzyme Precursors Insulin Complement Factor B

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Raum D

Alper C A

Stein R

Gabbay K H

Article Info

Journal

Lancet (London, England)

Abbr.

Lancet

ISSN

0140-6736

DOI

10.1016/s0140-6736(79)91895-6

Published

1979-06-09

Pages

1208-10

Language

English

Region

England

NLM ID

2985213R

Subset

External Links

PubMed source DOI: 10.1016/s0140-6736(79)91895-6 View journal details

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