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PMID: 8780729 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.

Biochemical and biophysical research communications ·Vol. 225 ·No. 3 ·1996-08-23 ·Pages 1035-9

Takeshita T, Arita T, Asao H, Tanaka N, Higuchi M, Kuroda H, Kaneko K, Munakata H, Endo Y, Fujita T, Sugamura K

Abstract

We molecularly cloned a cDNA coding for a novel phosphotyrosine molecule with a 70 kDa molecular mass, named STAM (signal transducing adaptor molecule), which is tyrosine-phosphorylated rapidly after stimulation with various cytokines such as IL-2, IL-3, IL-4, IL-7, GM-CSF, EGF and PDGF. STAM contains an SH3 (Src-homology 3) domain and the ITAM (immunoreceptor tyrosine-based activation motif), suggesting that STAM acts as an adaptor molecule involved in signal transducing pathways from the cytokine receptors.

MeSH Terms

Adaptor Proteins, Signal Transducing Amino Acid Sequence Animals Cell Line Chromosome Mapping Cloning, Molecular Cytokines/pharmacology DNA, Complementary/genetics Endosomal Sorting Complexes Required for Transport Humans Mice Molecular Sequence Data Molecular Weight Phosphoproteins/chemistry,genetics,metabolism Phosphorylation Proteins/chemistry,genetics,metabolism Receptors, Cytokine/metabolism Sequence Homology, Amino Acid Signal Transduction Tyrosine/metabolism src Homology Domains

Chemicals

Adaptor Proteins, Signal Transducing Cytokines DNA, Complementary Endosomal Sorting Complexes Required for Transport Phosphoproteins Proteins Receptors, Cytokine STAM protein, human Stam protein, mouse Tyrosine

Authors & Affiliations

11 authors, click to expand affiliations / ORCID

Takeshita T

Department of Microbiology, Tohoku University School of Medicine, Sendai, Japan.

Arita T

Asao H

Tanaka N

Higuchi M

Kuroda H

Kaneko K

Munakata H

Endo Y

Fujita T

Sugamura K

Article Info

Journal

Biochemical and biophysical research communications

Abbr.

Biochem Biophys Res Commun

ISSN

0006-291X

DOI

10.1006/bbrc.1996.1290

Published

1996-08-23

Pages

1035-9

Language

English

Region

United States

NLM ID

0372516

Subset

Databases

GENBANK

U43899, U43900

External Links

PubMed source DOI: 10.1006/bbrc.1996.1290 View journal details

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Cloning of a novel signal-transducing adaptor molecule containing an SH3 domain and ITAM.

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