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PMID: 8781237 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Neurogenic amplification of immune complex inflammation.

Science (New York, N.Y.) ·Vol. 273 ·No. 5282 ·1996-09-20 ·Pages 1722-5

Bozic CR, Lu B, Höpken UE, Gerard C, Gerard NP

Abstract

The formation of intrapulmonary immune complexes in mice generates a vigorous inflammatory response characterized by microvascular permeability and polymorphonuclear neutrophil influx. Gene-targeted disruption of the substance P receptor (NK-1R) protected the lung from immune complex injury, as did disruption of the C5a anaphylatoxin receptor. Immunoreactive substance P was measurable in fluids lining the lung at time points before neutrophil influx and may thus be involved in an early step in the inflammatory response to immune complexes in the lung.

MeSH Terms
Animals Antigen-Antibody Complex/immunology Antigens, CD/genetics,physiology Bronchoalveolar Lavage Fluid/chemistry Capillary Permeability Complement C5a/physiology Female Gene Targeting Immune Complex Diseases/immunology,metabolism,pathology Inflammation/immunology,metabolism,pathology Lung/chemistry,pathology Lung Diseases/immunology,metabolism,pathology Male Mice Mice, Inbred C57BL Neutrophils Receptor, Anaphylatoxin C5a Receptors, Complement/genetics,physiology Receptors, Neurokinin-1/genetics,physiology Substance P/analysis,physiology Tumor Necrosis Factor-alpha/analysis
Chemicals
Antigen-Antibody Complex Antigens, CD Receptor, Anaphylatoxin C5a Receptors, Complement Receptors, Neurokinin-1 Tumor Necrosis Factor-alpha Substance P Complement C5a
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Bozic C R
Perlmutter Laboratory, Children's Hospital, 300 Longwood Avenue, Boston, MA 02115, USA.
Lu B
Höpken U E
Gerard C
Gerard N P
Article Info
Journal
Science (New York, N.Y.)
Abbr.
Science
ISSN
0036-8075
DOI
10.1126/science.273.5282.1722
Published
1996-09-20
Pages
1722-5
Language
English
Region
United States
NLM ID
0404511
Subset
IM
Grants
NHLBI NIH HHS · HL36162 · United States
NHLBI NIH HHS · HL51366 · United States
External Links
PubMed source DOI: 10.1126/science.273.5282.1722 View journal details
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