Home LiteratureArticle Details

PMID: 8784346 Published · ppublish English Letter Research Support, Non-U.S. Gov't

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.

Nature structural biology ·Vol. 3 ·No. 9 ·1996-09-00 ·Pages 747-52

Hrabal R, Chen Z, James S, Bennett HP, Ni F

Abstract

The granulin/epithelin protein motif has an unusual structure consisting of a parallel stack of beta-hairpins stapled together by six disulphide bonds. The new structure also contains a folding subdomain shared by small toxins, protease inhibitors as well as the EGF-like protein modules.

MeSH Terms

Amino Acid Sequence Animals Carps Granulins Intercellular Signaling Peptides and Proteins Magnetic Resonance Spectroscopy Molecular Sequence Data Protein Structure, Secondary Proteins/chemistry

Chemicals

Granulins Intercellular Signaling Peptides and Proteins Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Hrabal R

Chen Z

James S

Bennett H P

Ni F

Article Info

Journal

Nature structural biology

Abbr.

Nat Struct Biol

ISSN

1072-8368

DOI

10.1038/nsb0996-747

Published

1996-09-00

Pages

747-52

Language

English

Region

United States

NLM ID

9421566

Subset

External Links

PubMed source DOI: 10.1038/nsb0996-747

Analysis Services

The hairpin stack fold, a novel protein architecture for a new family of protein growth factors.

Contact

WeChat Official Account