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PMID: 8787151 Published · ppublish English Journal Article

Regional cerebral glucose metabolism and postmortem pathology in Alzheimer's disease.

Acta neuropathologica ·Vol. 91 ·No. 2 ·1996-00-00 ·Pages 174-9

Mielke R, Schröder R, Fink GR, Kessler J, Herholz K, Heiss WD

Abstract

In four patients with an antemortem diagnosis of probable Alzheimer's disease (AD) regional cerebral glucose metabolism (rCMRGl) was studied prospectively by positron emission tomography (PET) and compared with postmortem semiquantitative neuropathology. The interval between the last PET study and autopsy was 1.3 +/- 0.8 years. In comparison with age-matched controls, the AD patients showed predominant temporoparietal hypometabolism spreading to other cortical and subcortical regions during serial PET scans. All patients had neuropathological findings typical for AD. There was a significant relationship between rCMRGl and density of senile plaques (SP) in one patient (tau b = -0.86, P < 0.05). SP were distributed quite homogeneously in all regions examined. Neurofibrillary tangles (NFT) were concentrated focally in the hippocampus-amygdala-entorhinal complex. In the context of widespread developing cortical hypometabolism, the predilection of NFT for involvement in limbic areas suggests a disruption of projection neurons as the pathogenetic process of cortical dysfunction.

MeSH Terms
Aged Alzheimer Disease/pathology Cerebral Cortex/pathology Female Glucose/metabolism Humans Male Middle Aged Neurofibrillary Tangles/pathology
Chemicals
Glucose
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Mielke R
Max-Planck-Institut für Neurologische Forschung, Köln, Germany.
Schröder R
Fink G R
Kessler J
Herholz K
Heiss W D
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Article Info
Journal
Acta neuropathologica
Abbr.
Acta Neuropathol
ISSN
0001-6322
DOI
10.1007/s004010050410
Published
1996-00-00
Pages
174-9
Language
English
Region
Germany
NLM ID
0412041
Subset
IM
External Links
PubMed source DOI: 10.1007/s004010050410 View journal details
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