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PMID: 8787683 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Insulin sensitivity index, acute insulin response, and glucose effectiveness in a population-based sample of 380 young healthy Caucasians. Analysis of the impact of gender, body fat, physical fitness, and life-style factors.

The Journal of clinical investigation ·Vol. 98 ·No. 5 ·1996-09-01 ·Pages 1195-209

Clausen JO, Borch-Johnsen K, Ibsen H, Bergman RN, Hougaard P, Winther K, Pedersen O

Abstract

Insulin sensitivity and insulin secretion are traits that are both genetically and environmentally determined. The aim of this study was to describe the distribution of the insulin sensitivity index (Si), the acute insulin response, and glucose effectiveness (Sg) in young healthy Caucasians and to estimate the relative impact of anthropometric and environmental determinants on these variables. The material included 380 unrelated Caucasian subjects (18-32 yr) with measurement of Si, Sg and insulin secretion during a combined intravenous glucose (0.3 grams/kg body weight) and tolbutamide (3 mg/kg body weight) tolerance test. The distributions of Si and acute insulin response were skewed to the right, whereas the distribution of Sg was Gaussian distributed. Sg was 15% higher in women compared with men (P < 0.001). Waist circumference, body mass index, maximal aerobic capacity, and women's use of oral contraceptives were the most important determinants of Si. Approximately one-third of the variation of Si could be explained by these factors. Compared with individuals in the upper four-fifths of the distribution of Si, subjects with Si in the lowest fifth had higher waist circumference, higher blood pressure, lower VO2max, and lower glucose tolerance and fasting dyslipidemia and dysfibrinolysis. Only 10% of the variation in acute insulin response could be explained by measured determinants. Estimates of body fat, maximal aerobic capacity, and women's use of oral contraceptives explain about one-third of the variation in Si in a population-based sample of young healthy Caucasians.

MeSH Terms
Adolescent Adult Arteriosclerosis/etiology Body Mass Index Demography Denmark Diabetes Mellitus/etiology Epidemiologic Factors Female Glucose/metabolism,pharmacokinetics Glucose Tolerance Test Humans Insulin/metabolism,pharmacology Insulin Resistance/physiology Insulin Secretion Life Style Male Metabolic Clearance Rate Physical Fitness Sex Characteristics Statistics, Nonparametric Whites
Chemicals
Insulin Glucose
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Clausen J O
Medical Department C, Glostrup Hospital, University of Copenhagen, Denmark.
Borch-Johnsen K
Ibsen H
Bergman R N
Hougaard P
Winther K
Pedersen O
References (65)
65 references, click to expand
  1. Insulin sensitivity and body fat distribution in normotensive offspring of hypertensive parents.
    Lancet. 1993 Feb 6;341(8841):327-31 PMID: 8094112
  2. Effects of testosterone on muscle insulin sensitivity and morphology in female rats.
    Am J Physiol. 1990 Oct;259(4 Pt 1):E555-60 PMID: 2221057
  3. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge.
    Clin Chem. 1972 Jun;18(6):499-502 PMID: 4337382
  4. Production of antisera to synthetic benzyloxycarbonyl-C-peptide of human proinsulin.
    Hoppe Seylers Z Physiol Chem. 1976 Jun;357(6):751-7 PMID: 986357
  5. Characterization of seven C-peptide antisera.
    Diabetes. 1978;27 Suppl 1:170-7 PMID: 564799
  6. Quantitative estimation of insulin sensitivity.
    Am J Physiol. 1979 Jun;236(6):E667-77 PMID: 443421
  7. Enzyme immunoassay for intact human insulin in serum or plasma.
    Clin Chem. 1993 Apr;39(4):578-82 PMID: 8472350
  8. Role of insulin resistance in human disease (syndrome X): an expanded definition.
    Annu Rev Med. 1993;44:121-31 PMID: 8476236
  9. Androgens, the metabolic syndrome, and non-insulin-dependent diabetes mellitus.
    Ann N Y Acad Sci. 1993 Mar 15;676:242-52 PMID: 8489135
  10. Relationship of dietary saturated fatty acids and body habitus to serum insulin concentrations: the Normative Aging Study.
    Am J Clin Nutr. 1993 Aug;58(2):129-36 PMID: 8338037
  11. Genetic and environmental determinants of non-insulin-dependent diabetes mellitus (NIDDM).
    Diabetes Metab Rev. 1992 Dec;8(4):287-338 PMID: 1307522
  12. An epidemiological perspective of the relationship between physical activity and NIDDM: from activity assessment to intervention.
    Diabetes Metab Rev. 1992 Dec;8(4):355-72 PMID: 1307524
  13. Abdominal obesity is associated with insulin resistance and reduced glycogen synthetase activity in skeletal muscle.
    Metabolism. 1993 Aug;42(8):998-1005 PMID: 8345824
  14. Quantification of the relationship between insulin sensitivity and beta-cell function in human subjects. Evidence for a hyperbolic function.
    Diabetes. 1993 Nov;42(11):1663-72 PMID: 8405710
  15. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians.
    N Engl J Med. 1993 Dec 30;329(27):1988-92 PMID: 8247074
  16. The contribution of insulin-dependent and insulin-independent glucose uptake to intravenous glucose tolerance in healthy human subjects.
    Diabetes. 1994 Apr;43(4):587-92 PMID: 8138065
  17. Insulin sensitivity, insulin secretion, and glucose effectiveness in subjects with impaired glucose tolerance: a minimal model analysis.
    Metabolism. 1994 Jun;43(6):714-8 PMID: 8201959
  18. Increased glucose effectiveness in normoglycemic but insulin-resistant relatives of patients with non-insulin-dependent diabetes mellitus. A novel compensatory mechanism.
    J Clin Invest. 1994 Sep;94(3):1196-204 PMID: 8083360
  19. Repeatability of insulin sensitivity and glucose effectiveness from the minimal model. Implications for study design.
    Diabetes. 1994 Nov;43(11):1365-71 PMID: 7926313
  20. Obesity, fat distribution, and weight gain as risk factors for clinical diabetes in men.
    Diabetes Care. 1994 Sep;17(9):961-9 PMID: 7988316
  21. Gender and insulin sensitivity in the heart and in skeletal muscles. Studies using positron emission tomography.
    Diabetes. 1995 Jan;44(1):31-6 PMID: 7813811
  22. Pathophysiology and pathogenesis of visceral fat obesity.
    Diabetes Res Clin Pract. 1994 Oct;24 Suppl:S111-6 PMID: 7859591
  23. Insulin resistance: interactions between obesity and a common variant of insulin receptor substrate-1.
    Lancet. 1995 Aug 12;346(8972):397-402 PMID: 7623569
  24. Comparison of the minimal model and the hyperglycemic clamp for measuring insulin sensitivity and acute insulin response to glucose.
    Metabolism. 1995 Sep;44(9):1121-5 PMID: 7666784
  25. The importance of adrenaline, insulin and insulin sensitivity as determinants for blood pressure in young Danes.
    J Hypertens. 1995 May;13(5):499-505 PMID: 7561006
  26. A nomogram for calculation of aerobic capacity (physical fitness) from pulse rate during sub-maximal work.
    J Appl Physiol. 1954 Sep;7(2):218-21 PMID: 13211501
  27. Intravenous glucose tolerance as a tool in definition and diagnosis of diabetes mellitus.
    Br Med J. 1962 Jun 2;1(5291):1507-13 PMID: 14467359
  28. Physiologic evaluation of factors controlling glucose tolerance in man: measurement of insulin sensitivity and beta-cell glucose sensitivity from the response to intravenous glucose.
    J Clin Invest. 1981 Dec;68(6):1456-67 PMID: 7033284
  29. Obesity as an independent risk factor for cardiovascular disease: a 26-year follow-up of participants in the Framingham Heart Study.
    Circulation. 1983 May;67(5):968-77 PMID: 6219830
  30. Demonstration of a relationship between level of physical training and insulin-stimulated glucose utilization in normal humans.
    Diabetes. 1983 May;32(5):408-11 PMID: 6341123
  31. Sex and insulin sensitivity.
    Metabolism. 1984 Nov;33(11):1011-5 PMID: 6387364
  32. Increased plasma levels of a rapid inhibitor of tissue plasminogen activator in young survivors of myocardial infarction.
    N Engl J Med. 1985 Dec 19;313(25):1557-63 PMID: 3934538
  33. Statistical methods for assessing agreement between two methods of clinical measurement.
    Lancet. 1986 Feb 8;1(8476):307-10 PMID: 2868172
  34. The insulin sensitivity index in nondiabetic man. Correlation between clamp-derived and IVGTT-derived values.
    Diabetes. 1986 Mar;35(3):362-9 PMID: 3512346
  35. Effects of exercise on glucose tolerance and insulin resistance. Brief review and some preliminary results.
    Acta Med Scand Suppl. 1986;711:55-65 PMID: 3535414
  36. Age dependence of tissue plasminogen activator concentrations in plasma, as studied by an improved enzyme-linked immunosorbent assay.
    Clin Chem. 1986 Dec;32(12):2160-5 PMID: 3096611
  37. MINMOD: a computer program to calculate insulin sensitivity and pancreatic responsivity from the frequently sampled intravenous glucose tolerance test.
    Comput Methods Programs Biomed. 1986 Oct;23(2):113-22 PMID: 3640682
  38. Equivalence of the insulin sensitivity index in man derived by the minimal model method and the euglycemic glucose clamp.
    J Clin Invest. 1987 Mar;79(3):790-800 PMID: 3546379
  39. Variations in insulin-stimulated glucose uptake in healthy individuals with normal glucose tolerance.
    J Clin Endocrinol Metab. 1987 Jun;64(6):1169-73 PMID: 3553221
  40. In vivo insulin action is familial characteristic in nondiabetic Pima Indians.
    Diabetes. 1987 Nov;36(11):1329-35 PMID: 3311855
  41. Improved insulin action in muscle, liver, and adipose tissue in physically trained human subjects.
    Am J Physiol. 1987 Nov;253(5 Pt 1):E489-95 PMID: 3318492
  42. Modified protocols improve insulin sensitivity estimation using the minimal model.
    Am J Physiol. 1987 Dec;253(6 Pt 1):E595-602 PMID: 2892414
  43. Risk factors for type 2 (non-insulin-dependent) diabetes mellitus. Thirteen and one-half years of follow-up of the participants in a study of Swedish men born in 1913.
    Diabetologia. 1988 Nov;31(11):798-805 PMID: 3234634
  44. Independent effects of weight change and attained body weight on prevalence of arterial hypertension in obese and non-obese men.
    BMJ. 1989 Sep 23;299(6702):767-70 PMID: 2508915
  45. Epidemiology, obesity, and non-insulin-dependent diabetes mellitus.
    Epidemiol Rev. 1989;11:172-81 PMID: 2680554
  46. Lilly lecture 1989. Toward physiological understanding of glucose tolerance. Minimal-model approach.
    Diabetes. 1989 Dec;38(12):1512-27 PMID: 2684710
  47. Inter and intra individual variability of acute insulin response during intravenous glucose tolerance tests.
    Diabete Metab. 1989 Sep-Oct;15(5):224-32 PMID: 2698364
  48. Blood pressure in Danish children and adolescents.
    Acta Paediatr Scand. 1981 Jan;70(1):27-31 PMID: 7211377
  49. A longitudinal epidemiological survey of relative weight at age 25,50 and 60 in the Glostrup population of men and women born in 1914.
    Dan Med Bull. 1981 Aug;28(3):106-16 PMID: 7273866
  50. Factors associated with the initial blood pressure level and with the subsequent blood pressure increase in a longitudinal population study. The study of men born in 1913.
    Eur Heart J. 1980 Oct;1(5):345-54 PMID: 7274247
  51. Prediction of body water and fat in adult Danes from measurement of electrical impedance. A validation study.
    Int J Obes. 1990 Sep;14(9):789-802 PMID: 2228410
  52. Slow glucose removal rate and hyperinsulinemia precede the development of type II diabetes in the offspring of diabetic parents.
    Ann Intern Med. 1990 Dec 15;113(12):909-15 PMID: 2240915
  53. Insulin resistance. A multifaceted syndrome responsible for NIDDM, obesity, hypertension, dyslipidemia, and atherosclerotic cardiovascular disease.
    Diabetes Care. 1991 Mar;14(3):173-94 PMID: 2044434
  54. Genetics of non-insulin dependent diabetes mellitus.
    Baillieres Clin Endocrinol Metab. 1991 Sep;5(3):455-76 PMID: 1892472
  55. Reproducibility of insulin sensitivity measured by the minimal model method.
    Diabetologia. 1991 Jul;34(7):527-30 PMID: 1916059
  56. Altered insulin sensitivity, hyperinsulinemia, and dyslipidemia in individuals with a hypertensive parent.
    Am J Med. 1991 Dec;91(6):589-96 PMID: 1750428
  57. Insulin resistance, secretion, and metabolism in users of oral contraceptives.
    J Clin Endocrinol Metab. 1992 Jan;74(1):64-70 PMID: 1530790
  58. Insulin sensitivity, glucose effectiveness, and body fat distribution pattern in nondiabetic offspring of patients with NIDDM.
    Diabetes Care. 1991 Oct;14(10):890-6 PMID: 1773687
  59. Pathogenesis of NIDDM. A balanced overview.
    Diabetes Care. 1992 Mar;15(3):318-68 PMID: 1532777
  60. Insulin resistance and cigarette smoking.
    Lancet. 1992 May 9;339(8802):1128-30 PMID: 1349365
  61. Effect of body mass index and fat distribution on insulin sensitivity, secretion, and clearance in nonobese healthy men.
    J Clin Endocrinol Metab. 1992 Jul;75(1):170-5 PMID: 1619007
  62. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a 25-year follow-up study.
    Lancet. 1992 Oct 17;340(8825):925-9 PMID: 1357346
  63. Effect of gender on insulin resistance associated with aging.
    Am J Physiol. 1992 Oct;263(4 Pt 1):E780-5 PMID: 1415700
  64. Reduced sample number for calculation of insulin sensitivity and glucose effectiveness from the minimal model. Suitability for use in population studies.
    Diabetes. 1993 Feb;42(2):250-6 PMID: 8425661
  65. The effects of testosterone on insulin sensitivity in male rats.
    Acta Physiol Scand. 1992 Dec;146(4):505-10 PMID: 1492567
Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI118903
Published
1996-09-01
Pages
1195-209
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC507542
Subset
IM
Grants
NIDDK NIH HHS · DK 29867 · United States
External Links
PubMed source DOI: 10.1172/JCI118903 PMC Full Text View journal details
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