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PMID: 8790444 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Schizophrenia and cognitive dysmetria: a positron-emission tomography study of dysfunctional prefrontal-thalamic-cerebellar circuitry.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 18 ·1996-09-03 ·Pages 9985-90

Andreasen NC, O'Leary DS, Cizadlo T, Arndt S, Rezai K, Ponto LL, Watkins GL, Hichwa RD

Abstract

Patients suffering from schizophrenia display subtle cognitive abnormalities that may reflect a difficulty in rapidly coordinating the steps that occur in a variety of mental activities. Working interactively with the prefrontal cortex, the cerebellum may play a role in coordinating both motor and cognitive performance. This positron-emission tomography study suggests the presence of a prefrontal-thalamic-cerebellar network that is activated when normal subjects recall complex narrative material, but is dysfunctional in schizophrenic patients when they perform the same task. These results support a role for the cerebellum in cognitive functions and suggest that patients with schizophrenia may suffer from a "cognitive dysmetria" due to dysfunctional prefrontal-thalamic-cerebellar circuitry.

MeSH Terms
Adult Cerebellum/diagnostic imaging Cognition Disorders/diagnostic imaging Female Humans Magnetic Resonance Imaging Male Memory Prefrontal Cortex/diagnostic imaging Radiography Schizophrenia/diagnostic imaging Thalamus/diagnostic imaging Tomography, Emission-Computed
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Andreasen N C
Mental Health Clinical Research Center, University of Iowa College of Medicine and Hospitals and Clinics, Iowa City 52242, USA.
O'Leary D S
Cizadlo T
Arndt S
Rezai K
Ponto L L
Watkins G L
Hichwa R D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.18.9985
Published
1996-09-03
Pages
9985-90
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC38542
Subset
IM
Grants
NIMH NIH HHS · MH31593 · United States
NIMH NIH HHS · MH40856 · United States
NIMH NIH HHS · MHCRC43271 · United States
External Links
PubMed source DOI: 10.1073/pnas.93.18.9985 PMC Full Text View journal details
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