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PMID: 8791529 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Conservation of dorsal-ventral patterning in arthropods and chordates.

Current opinion in genetics & development ·Vol. 6 ·No. 4 ·1996-08-00 ·Pages 424-31

Ferguson EL

Abstract

Dorsal-ventral patterning within the ectodermal and mesodermal germ layers of Drosophila and Xenopus embryos is specified by a system of genes that has been conserved over 500 million years of evolution. In both organisms, the activity of the TGF-beta family member DPP/BMP4 is antagonized by SOG/CHORDIN. A second Xenopus gene, noggin, has a similar biological activity to chordin. Analysis of the action of these genes indicate that Spemann's organizer promotes dorsal cell fates in Xenopus by antagonizing a ventralizing signal encoded by the Bmp4 gene.

MeSH Terms
Animals Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins/genetics,metabolism Carrier Proteins Drosophila/embryology,genetics,metabolism Drosophila Proteins Ectoderm Glycoproteins Growth Substances/genetics,metabolism Humans Insect Proteins/genetics,metabolism Intercellular Signaling Peptides and Proteins Mesoderm Proteins/genetics,metabolism Signal Transduction Transforming Growth Factor beta/genetics,metabolism Xenopus/embryology,genetics,metabolism Xenopus Proteins Zygote
Chemicals
BMP4 protein, human Bone Morphogenetic Protein 4 Bone Morphogenetic Proteins Carrier Proteins Drosophila Proteins Glycoproteins Growth Substances Insect Proteins Intercellular Signaling Peptides and Proteins Proteins Transforming Growth Factor beta Xenopus Proteins bmp4 protein, Xenopus dpp protein, Drosophila sog protein, Drosophila noggin protein chordin
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ferguson E L
Department of Molecular Genetics, University of Chicago, 920 East 58th Street, Chicago, Illinois 60637, USA. [email protected]
Article Info
Journal
Current opinion in genetics & development
Abbr.
Curr Opin Genet Dev
ISSN
0959-437X
DOI
10.1016/s0959-437x(96)80063-3
Email
[email protected]
Published
1996-08-00
Pages
424-31
Language
English
Region
England
NLM ID
9111375
Subset
IM
External Links
PubMed source DOI: 10.1016/s0959-437x(96)80063-3 View journal details
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