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PMID: 879268 Published · ppublish English Case Reports Journal Article

Ultrastructure in glomerulonephritis associated with cryoglobulinemia. A report of six cases and review of the literature.

The American journal of pathology ·Vol. 88 ·No. 1 ·1977-07-00 ·Pages 145-62

Feiner H, Gallo G

Abstract

Renal tissue from 6 patients with glomerulonephritis associated with cryoglobulinemia was studied by light microscopy, immunofluorescence microscopy, and electron microscopy. Fibrillar deposits in glomerular capillaries were observed in electron micrographs in 4 of 6 patients. The ultrastructure of these deposits is compared with those in 6 previously reported cases, with the ultrastructure of the serum cryoprecipitates, and with fibrillar glomerular deposits in other glomerulonephritides. It is concluded that serum cryoprecipitates are structurally similar to glomerular deposits and that these fibrillar deposits are a frequent and possibly distinguishing morphologic feature of glomerulonephritis associated with cryoglobulinemia.

MeSH Terms
Adult Aged Chemical Precipitation Cryoglobulins Female Glomerulonephritis/complications,pathology Humans Immunoglobulin G Immunoglobulin M Kidney Glomerulus/ultrastructure Male Middle Aged Paraproteinemias/etiology,pathology
Chemicals
Cryoglobulins Immunoglobulin G Immunoglobulin M
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Feiner H
Gallo G
References (27)
27 references, click to expand
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Article Info
Journal
The American journal of pathology
Abbr.
Am J Pathol
ISSN
0002-9440
Published
1977-07-00
Pages
145-62
Language
English
Region
United States
NLM ID
0370502
PMCID
PMC2032161
Subset
IM
External Links
PubMed source PMC Full Text View journal details
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