Intracellular signalling: putting JAKs on the kinase MAP.

Current biology : CB ·Vol. 6 ·No. 6 ·1996-06-01 ·Pages 668-71

Winston LA, Hunter T

Abstract

Tyrosine kinases of the JAK family are required for activation of both STAT transcription factors and the ERK/MAP kinase pathway, suggesting a mechanism for the optimization of gene induction via the coordinate activation of multiple transcription factors.

MeSH Terms

Animals Calcium-Calmodulin-Dependent Protein Kinases/metabolism Humans Janus Kinase 3 Protein Serine-Threonine Kinases/metabolism Protein-Tyrosine Kinases/metabolism Proto-Oncogene Proteins/metabolism Proto-Oncogene Proteins c-raf Signal Transduction/physiology Transcription Factors/metabolism Transcription, Genetic ras Proteins/metabolism

Chemicals

Proto-Oncogene Proteins Transcription Factors Protein-Tyrosine Kinases JAK3 protein, human Janus Kinase 3 Protein Serine-Threonine Kinases Proto-Oncogene Proteins c-raf Calcium-Calmodulin-Dependent Protein Kinases ras Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Winston L A

Molecular Biology & Virology Laboratory, Salk Institute for Biological Studies, La Jolla, California 92037, USA.

Hunter T

Article Info

Journal

Current biology : CB

Abbr.

Curr Biol

ISSN

0960-9822

DOI

10.1016/s0960-9822(09)00445-x

Published

1996-06-01

Pages

668-71

Language

English

Region

England

NLM ID

9107782

Subset

External Links

PubMed source DOI: 10.1016/s0960-9822(09)00445-x View journal details

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