Understanding and controlling the cell cycle with natural products.

Chemistry & biology ·Vol. 3 ·No. 8 ·1996-08-00 ·Pages 623-39

Hung DT, Jamison TF, Schreiber SL

Abstract

Small molecule natural products have aided in the discovery and characterization of many proteins critical to the progression and maintenance of the cell cycle. Identification of the direct target of a natural product gives scientists a tool to control a specific aspect of the cell cycle, thus facilitating the study of the cell-cycle machinery.

MeSH Terms

Animals Apoptosis/drug effects,physiology Biological Products/chemistry,pharmacology,physiology Cell Cycle/drug effects,physiology DNA Damage Molecular Structure Nucleic Acid Synthesis Inhibitors/chemistry,pharmacology Signal Transduction/drug effects,physiology

Chemicals

Biological Products Nucleic Acid Synthesis Inhibitors

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Hung D T

Howard Hughes Medical Institute, Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA 02138, USA.

Jamison T F

Schreiber S L

Article Info

Journal

Chemistry & biology

Abbr.

Chem Biol

ISSN

1074-5521

DOI

10.1016/s1074-5521(96)90129-5

Published

1996-08-00

Pages

623-39

Language

English

Region

United States

NLM ID

9500160

Subset

External Links

PubMed source DOI: 10.1016/s1074-5521(96)90129-5 View journal details

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