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PMID: 8821095 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Contributions of tumor and stromal matrix metalloproteinases to tumor progression, invasion and metastasis.

Cancer metastasis reviews ·Vol. 14 ·No. 4 ·1995-12-00 ·Pages 351-62

MacDougall JR, Matrisian LM

Abstract

The malignant progression of tumors is driven by the expression of oncogenes and loss of expression of tumor suppressor genes; factors that are intrinsic to cancer cells. The phenotypic changes brought about by the gain or loss of expression of oncogenes and tumor suppressor genes lead to the acquisition of malignant traits, namely, the ability to invade into and grow in ectopic tissue environments. Recently, however, focus in cancer research has widened from the cancer cell to include the surrounding tumor stroma as an integral player in the process of tumor progression. One of the areas in cancer research contributing to this enhanced appreciation of stromal involvement in tumor progression and metastasis is that of matrix metalloproteinases (MMPs). This review provides an overview of the characteristics of MMPs and discusses their role in the progression and metastasis of tumors. Initially, attention will focus on the regulation of MMPs in tumor cells but will switch to discourse on stromal expression of MMPs in tumors and speculation on the functional consequences of stromal expression of MMPs.

MeSH Terms
Amino Acid Sequence Disease Progression Extracellular Matrix/enzymology Metalloendopeptidases/physiology Molecular Sequence Data Neoplasm Invasiveness Neoplasm Metastasis Neoplasms/enzymology,pathology Stromal Cells/enzymology
Chemicals
Metalloendopeptidases
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
MacDougall J R
Department of Cell Biology, Vanderbilt University, Nashville, Tennessee 37232-2175, USA.
Matrisian L M
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Article Info
Journal
Cancer metastasis reviews
Abbr.
Cancer Metastasis Rev
ISSN
0167-7659
DOI
10.1007/BF00690603
Published
1995-12-00
Pages
351-62
Language
English
Region
Netherlands
NLM ID
8605731
Subset
IM
Grants
NCI NIH HHS · CA 46843 · United States
NCI NIH HHS · R01-CA60867 · United States
External Links
PubMed source DOI: 10.1007/BF00690603 View journal details
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