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PMID: 8824794 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

Regulation of Epstein-Barr virus latency by latent membrane protein 2.

Trends in microbiology ·Vol. 4 ·No. 1 ·1996-01-00 ·Pages 38-42

Longnecker R, Miller CL

Abstract

Like other herpesviruses, Epstein-Barr virus persists in its host through its ability to establish a latent infection that periodically reactivates. Latent membrane protein 2A (LMP2A) regulates reactivation from latency by interfering with normal B cell signal transduction processes, and may define a new class of regulators of herpesvirus latency.

MeSH Terms

Amino Acid Sequence Animals B-Lymphocytes/immunology Gene Expression Regulation, Viral Genes, Viral/genetics Herpesviridae Infections/immunology,virology Herpesvirus 4, Human/immunology,physiology Humans Molecular Sequence Data Signal Transduction Viral Matrix Proteins/genetics,immunology Virus Latency/physiology

Chemicals

EBV-associated membrane antigen, Epstein-Barr virus Viral Matrix Proteins

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Longnecker R

Microbiology-Immunology Dept, Northwestern University Medical School, Chicago, IL 60611, USA. [email protected]

Miller C L

Article Info

Journal

Trends in microbiology

Abbr.

Trends Microbiol

ISSN

0966-842X

DOI

10.1016/0966-842x(96)81504-6

[email protected]

Published

1996-01-00

Pages

38-42

Language

English

Region

England

NLM ID

9310916

Subset

Grants

NCI NIH HHS · CA47006 · United States

NCI NIH HHS · CA62234 · United States

External Links

PubMed source DOI: 10.1016/0966-842x(96)81504-6 View journal details

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Regulation of Epstein-Barr virus latency by latent membrane protein 2.

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