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PMID: 8847998 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Accumulation of manganese and copper in pallidum of cirrhotic patients: role in the pathogenesis of hepatic encephalopathy?

Metabolic brain disease ·Vol. 10 ·No. 4 ·1995-12-00 ·Pages 353-6

Layrargues GP, Shapcott D, Spahr L, Butterworth RF

Abstract

Concentrations of zinc, copper and manganese were measured by atomic absorption spectrometry in samples of globus pallidus obtained at autopsy from 9 patients with chronic liver disease and an equal number of age-matched controls. Manganese concentrations were significantly increased several fold (p < 0.01) in globus pallidus of liver disease patients accompanied by smaller but significant 2-fold increases of copper. Zinc concentrations, on the other hand, were within normal limits. Increased pallidal manganese offers a cogent explanation for the observed T1-weighted MRI signal hyperintensity in pallidum of cirrhotic patients. Increased copper content in brain suggests the existence of common pathophysiologic mechanisms in inherited (Wilson Disease) and acquired hepatocerebral disorders.

MeSH Terms
Aged Copper/metabolism Globus Pallidus/metabolism,pathology Hepatic Encephalopathy/metabolism,pathology Humans Manganese/metabolism Middle Aged Spectrophotometry, Atomic
Chemicals
Manganese Copper
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Layrargues G P
Liver Unit, Hôpital Saint-Luc (University of Montreal), Quebec.
Shapcott D
Spahr L
Butterworth R F
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Article Info
Journal
Metabolic brain disease
Abbr.
Metab Brain Dis
ISSN
0885-7490
DOI
10.1007/BF02109365
Published
1995-12-00
Pages
353-6
Language
English
Region
United States
NLM ID
8610370
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02109365 View journal details
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