Selectin synthesis and inflammation.

Trends in biochemical sciences ·Vol. 21 ·No. 2 ·1996-02-00 ·Pages 65-9

Whelan J

Abstract

The selectins are a family of three cell-surface-presented glycoprotein receptors. They play a key role in the initial adhesive interaction between leukocytes and endothelial cells at sites of inflammation. The presence of selectins on the cell surface is tightly regulated and inappropriate appearance is associated with a number of inflammatory disease conditions.

MeSH Terms

Amino Acid Sequence Cell Adhesion Molecules/chemistry,metabolism Cytokines/metabolism,pharmacology E-Selectin/biosynthesis,chemistry,metabolism Endothelium/metabolism Gene Expression/genetics Glycoproteins/chemistry,metabolism Inflammation/metabolism L-Selectin/metabolism Leukocytes/chemistry,metabolism Membrane Proteins/chemistry,metabolism Models, Biological Molecular Sequence Data Oligosaccharides/metabolism P-Selectin/metabolism Promoter Regions, Genetic/genetics Sialyl Lewis X Antigen Signal Transduction Transcription Factors/genetics Transcription, Genetic/genetics

Chemicals

Cell Adhesion Molecules Cytokines E-Selectin Glycoproteins Membrane Proteins Oligosaccharides P-Selectin Sialyl Lewis X Antigen Transcription Factors L-Selectin

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Whelan J

Glaxo Institute for Molecular Biology, Geneva, Switzerland.

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

Published

1996-02-00

Pages

65-9

Language

English

Region

England

NLM ID

7610674

Subset

Corrections

ErratumIn

External Links

PubMed source View journal details

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Selectin synthesis and inflammation.

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