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PMID: 8862608 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The mtp40 gene is not present in all strains of Mycobacterium tuberculosis.

Journal of clinical microbiology ·Vol. 34 ·No. 9 ·1996-09-00 ·Pages 2309-11

Weil A, Plikaytis BB, Butler WR, Woodley CL, Shinnick TM

Abstract

A multiple PCR-based assay that targets IS6110 and the mtp40 gene was evaluated for the rapid differentiation of Mycobacterium bovis and M. tuberculosis, two of the causative agents of tuberculosis. The IS6110 target is present in both species, whereas the mtp40 gene was thought to be specific for M.tuberculosis (P. Del Portillo, L.A. Murillo, and M.E. Patarroyo, J. Clin. Microbiol. 29:2163-2168, 1991). However, the mtp-40 gene is not present in all M. tuberculosis strains and, hence, is not useful for differentiating M.tuberculosis and M.bovis.

MeSH Terms

Bacterial Proteins/genetics Bacterial Typing Techniques Genes, Bacterial Mycobacterium tuberculosis/classification,genetics Type C Phospholipases

Chemicals

Bacterial Proteins Type C Phospholipases MpcA protein, Mycobacterium tuberculosis

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Weil A

Emory University School of Medicine, Atlanta, Georgia 30322, USA.

Plikaytis B B

Butler W R

Woodley C L

Shinnick T M

References (11)

11 references, click to expand

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Transmission of multidrug-resistant Mycobacterium tuberculosis among persons with human immunodeficiency virus infection in an urban hospital: epidemiologic and restriction fragment length polymorphism analysis.
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Is Mycobacterium tuberculosis 15,000 years old?
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Article Info

Journal

Journal of clinical microbiology

Abbr.

J Clin Microbiol

ISSN

0095-1137

DOI

10.1128/jcm.34.9.2309-2311.1996

Published

1996-09-00

Pages

2309-11

Language

English

Region

United States

NLM ID

7505564

PMCID

PMC229241

Subset

Grants

NHLBI NIH HHS · K07 HL03078-01 · United States

External Links

PubMed source DOI: 10.1128/jcm.34.9.2309-2311.1996 PMC Full Text View journal details

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