Molecular cloning of two novel rab genes from human melanocytes.

Gene ·Vol. 174 ·No. 1 ·1996-09-26 ·Pages 129-34

Chen D, Guo J, Miki T, Tachibana M, Gahl WA

Abstract

We isolated the genes of two small GTP-binding proteins of the rab family from a human melanocyte cDNA library and from melanoma cells. One gene, rab30 codes for a novel rab protein of 203 amino acids with minimal homology to previously documented GTPases. The other, rab22b, appears to be an isoform of the human homologue of canine rab22. Both rab mRNAs displayed a nearly ubiquitous pattern of expression in the various tissues examined. Rab22b and rab30 were mapped to chromosomes 18 and 11, respectively.

MeSH Terms

Amino Acid Sequence Animals Base Sequence Cloning, Molecular Dogs GTP Phosphohydrolases/genetics GTP-Binding Proteins/genetics Humans Melanocytes/chemistry Melanoma/genetics Molecular Sequence Data Sequence Homology Tumor Cells, Cultured rab GTP-Binding Proteins

Chemicals

RAB22A protein, human RAB31 protein, human rab22 protein, Canis familiaris RAB30 protein, human GTP Phosphohydrolases GTP-Binding Proteins rab GTP-Binding Proteins

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Chen D

Section on Human Biochemical Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892-1830, USA.

Guo J

Miki T

Tachibana M

Gahl W A

Article Info

Journal

Gene

Abbr.

Gene

ISSN

0378-1119

DOI

10.1016/0378-1119(96)00509-4

Published

1996-09-26

Pages

129-34

Language

English

Region

Netherlands

NLM ID

7706761

Subset

Databases

GENBANK

U57091, U57092

External Links

PubMed source DOI: 10.1016/0378-1119(96)00509-4 View journal details

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Molecular cloning of two novel rab genes from human melanocytes.

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