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PMID: 8869881 Published · ppublish English Journal Article Review

Phosphatidate phosphatases of mammals, yeast, and higher plants.

Lipids ·Vol. 31 ·No. 8 ·1996-08-00 ·Pages 785-802

Kocsis MG, Weselake RJ

Abstract

Phosphatidate phosphatase (EC 3.1.3.4) catalyzes the hydrolysis of phosphatidate to yield sn-1,2-diacylglycerol and inorganic phosphate. In mammalian systems, forms of phosphatidate phosphatase involved in glycerolipid synthesis and signal transduction have been identified. Forms of the enzyme involved in signal transduction have been purified and partially characterized. In yeast, phosphatidate phosphatases associated with the endoplasmic reticulum and mitochondria have also been purified and partially characterized. Information on phosphatidate phosphatases from mammals and yeast is useful in characterizing the enzyme from plant systems. This review examines progress on the characterization of phosphatidate phosphatases from mammals, yeast, and higher plants. The purification and characterization of the phosphatidate phosphatase involved in glycerolipid synthesis in developing oilseeds may lead to the identification of the encoding gene. Increasing our understanding of the enzymes of lipid synthesis in developing seeds will aid in the development of biotechnological strategies for seed oil modification.

MeSH Terms
Animals Humans Lipid Metabolism Mammals Models, Chemical Phosphatidate Phosphatase/metabolism Plants Saccharomyces cerevisiae Signal Transduction
Chemicals
Phosphatidate Phosphatase
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kocsis M G
Department of Chemistry, University of Lethbridge, Alberta, Canada.
Weselake R J
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Article Info
Journal
Lipids
Abbr.
Lipids
ISSN
0024-4201
DOI
10.1007/BF02522974
Published
1996-08-00
Pages
785-802
Language
English
Region
United States
NLM ID
0060450
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02522974 View journal details
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