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PMID: 8880000 Published · ppublish English Journal Article Review

Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop.

Environmental health perspectives ·Vol. 104 Suppl 4 ·1996-08-00 ·Pages 715-40

Kavlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaattari S, Lucier G, Luster M, Mac MJ, Maczka C, Miller R, Moore J, Rolland R, Scott G, Sheehan DM, Sinks T, Tilson HA

Abstract

The hypothesis has been put forward that humans and wildlife species adverse suffered adverse health effects after exposure to endocrine-disrupting chemicals. Reported adverse effects include declines in populations, increases in cancers, and reduced reproductive function. The U.S. Environmental Protection Agency sponsored a workshop in April 1995 to bring together interested parties in an effort to identify research gaps related to this hypothesis and to establish priorities for future research activities. Approximately 90 invited participants were organized into work groups developed around the principal reported health effects-carcinogenesis, reproductive toxicity, neurotoxicity, and immunotoxicity-as well as along the risk assessment paradigm-hazard identification, dose-response assessment, exposure assessment, and risk characterization. Attention focused on both ecological and human health effects. In general, group felt that the hypothesis warranted a concerted research effort to evaluate its validity and that research should focus primarily on effects on development of reproductive capability, on improved exposure assessment, and on the effects of mixtures. This report summarizes the discussions of the work groups and details the recommendations for additional research.

MeSH Terms
Animals Education Endocrine Glands/drug effects Environment Environmental Pollutants/pharmacology Health Humans Research Risk Assessment United States United States Environmental Protection Agency
Chemicals
Environmental Pollutants
Authors & Affiliations
17 authors, click to expand affiliations / ORCID
Kavlock R J
National Health and Environmental Effects Research Laboratory, U.S. EPA, Research Triangle Park, NC 27711, USA. [email protected]
Daston G P
DeRosa C
Fenner-Crisp P
Gray L E
Kaattari S
Lucier G
Luster M
Mac M J
Maczka C
Miller R
Moore J
Rolland R
Scott G
Sheehan D M
Sinks T
Tilson H A
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Article Info
Journal
Environmental health perspectives
Abbr.
Environ Health Perspect
ISSN
0091-6765
DOI
10.1289/ehp.96104s4715
Email
[email protected]
Published
1996-08-00
Pages
715-40
Language
English
Region
United States
NLM ID
0330411
PMCID
PMC1469675
Subset
IM
External Links
PubMed source DOI: 10.1289/ehp.96104s4715 PMC Full Text View journal details
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