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PMID: 8891294 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Chronic nicotine treatment delays the developmental increase in brain muscarinic receptors in rat neonate.

Brain research ·Vol. 732 ·No. 1-2 ·1996-09-02 ·Pages 257-60

Zhu J, Takita M, Konishi Y, Sudo M, Muramatsu I

Abstract

Developmental increase in the muscarinic receptors ([3H]quinuclidinyl benzylate binding sites) of rat neonate brain (cerebral cortex and cerebellum) was significantly inhibited by chronic nicotine treatment of the dams during pregnancy and lactation. However, development of the nicotinic receptors ([3H]cytisine binding sites) was not inhibited and rather was up-regulated in the cerebral cortex and brainstem by the nicotine treatment. Such inhibition and up-regulation were not seen in nicotine-withdrawn rats after birth. These results suggest that nicotine treatment during lactation may cause a remarkable delay in development of muscarinic neurotransmission in rat neonates.

MeSH Terms
Aging/metabolism Alkaloids/metabolism Animals Animals, Newborn Azocines Brain/drug effects,growth & development,metabolism Brain Stem/metabolism Cerebellum/metabolism Cerebral Cortex/metabolism Female Gene Expression Regulation, Developmental/drug effects Hippocampus/metabolism Lactation Maternal-Fetal Exchange Mesencephalon/metabolism Nicotine/pharmacology Organ Specificity Pregnancy Prenatal Exposure Delayed Effects Quinolizines Quinuclidinyl Benzilate/metabolism Rats Rats, Wistar Receptors, Muscarinic/biosynthesis Up-Regulation
Chemicals
Alkaloids Azocines Quinolizines Receptors, Muscarinic cytisine Quinuclidinyl Benzilate Nicotine
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Zhu J
Department of Pharmacology, Fukui Medical School, Japan.
Takita M
Konishi Y
Sudo M
Muramatsu I
Article Info
Journal
Brain research
Abbr.
Brain Res
ISSN
0006-8993
DOI
10.1016/0006-8993(96)00704-4
Published
1996-09-02
Pages
257-60
Language
English
Region
Netherlands
NLM ID
0045503
Subset
IM
External Links
PubMed source DOI: 10.1016/0006-8993(96)00704-4 View journal details
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