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PMID: 8912529 Published · ppublish English Journal Article

Therapeutic effect of the matrix metalloproteinase inhibitor, batimastat, in a human colorectal cancer ascites model.

British journal of cancer ·Vol. 74 ·No. 9 ·1996-11-00 ·Pages 1354-8

Watson SA, Morris TM, Parsons SL, Steele RJ, Brown PD

Abstract

The matrix metalloproteinase inhibitor batimastat was administered to a human colorectal cancer ascites model, which was initiated by injection of C170HM2 cells into the peritoneal cavity of SCID mice and resulted in solid tumour deposits and ascites formation. The cell line expressed both the 72 and 92 kDa forms of gelatinase by zymography. Batimastat administered from day 0 (40 mg kg-1) reduced the volume of ascites to 21% of control in mice treated from day 0 (P < 0.002) but not day 10. Formation of solid peritoneal deposits was significantly reduced to 77% of vehicle control when batimastat was administered from day 0 (P < 0.01) and 69% of control when administered from day 10 (P < 0.05). Thus, batimastat has the ability to reduce the volume of ascites forming in SCID mice injected intraperitoneally with the human colorectal cell line, C170HM2, when administered from day 0 but not from day 10. Solid peritoneal tumour deposits were significantly reduced in both treatment groups, highlighting the therapeutic potential of batimastat in this clinical condition.

MeSH Terms
Animals Antineoplastic Agents/therapeutic use Ascitic Fluid/drug therapy,prevention & control Colorectal Neoplasms/complications Drug Screening Assays, Antitumor Female Humans Metalloendopeptidases/antagonists & inhibitors Mice Mice, SCID Phenylalanine/analogs & derivatives,therapeutic use Thiophenes/therapeutic use Tumor Cells, Cultured
Chemicals
Antineoplastic Agents Thiophenes Phenylalanine batimastat Metalloendopeptidases
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Watson S A
Department of Surgery, Queen's Medical Centre, Nottingham, UK.
Morris T M
Parsons S L
Steele R J
Brown P D
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18 references, click to expand
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Article Info
Journal
British journal of cancer
Abbr.
Br J Cancer
ISSN
0007-0920
Published
1996-11-00
Pages
1354-8
Language
English
Region
England
NLM ID
0370635
PMCID
PMC2074768
Subset
IM
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