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PMID: 8918187 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Diverse molecular provocation of programmed cell death.

Trends in biochemical sciences ·Vol. 21 ·No. 10 ·1996-10-00 ·Pages 359-64

Wertz IE, Hanley MR

Abstract

The experimental study and manipulation of programmed cell death has been greatly assisted by the identification of genetic and pharmacological tools that can either induce or block cell lethality. This review discusses new insights into the molecular sensing of perturbations induced by such tools, as well as the possible consequences of this detection in determining cell survival.

MeSH Terms

Amyloid/pharmacology Apoptosis/drug effects,genetics,physiology Chelating Agents/pharmacology Cytoskeleton/chemistry DNA Damage/genetics Ion Channels/metabolism Oxidants/pharmacology Receptors, Cell Surface/metabolism Signal Transduction/genetics Tumor Necrosis Factor-alpha/pharmacology

Chemicals

Amyloid Chelating Agents Ion Channels Oxidants Receptors, Cell Surface Tumor Necrosis Factor-alpha

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Wertz I E

Department of Biological Chemistry, School of Medicine, University of California at Davis 95616, USA.

Hanley M R

Article Info

Journal

Trends in biochemical sciences

Abbr.

Trends Biochem Sci

ISSN

0968-0004

Published

1996-10-00

Pages

359-64

Language

English

Region

England

NLM ID

7610674

Subset

External Links

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Diverse molecular provocation of programmed cell death.

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