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PMID: 8922403 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

D1/D5 dopamine receptor activation increases the magnitude of early long-term potentiation at CA1 hippocampal synapses.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 16 ·No. 23 ·1996-12-01 ·Pages 7478-86

Otmakhova NA, Lisman JE

Abstract

The role of the mesolimbic dopaminergic system in the reinforcement of learning suggests that dopamine should be able to modulate activity-dependent synaptic plasticity. We have examined the effect of D1/D5 agonists on early long-term potentiation (LTP) (40 min) in the CA1 region of hippocampal slices. D1/D5 agonists (+)bromo-APB, 6-chloro-PB, and dihydrexidine increased the magnitude of LTP in a synapse-specific manner (by approximately 10, 15, and 20%, respectively). This D1/D5 effect was mimicked by a low dose (10 microM) of the adenylyl cyclase activator forskolin. The D1/D5 antagonist (+)SCH 23390 reduced early LTP. In catecholamine-depleted slices, LTP was smaller by approximately 20-25% and could not be decreased further by D1/D5 antagonist. Under these conditions, D1/D5 agonist 6-chloro-PB and forskolin produced a larger enhancement of LTP (20-25%), restoring it to the control level. At the same dose, dideoxyforskolin did not affect early LTP. The D1/D5 agonist effect was completely blocked by the D1/D5 antagonist (+)SCH 23390. These results indicate that dopamine produces a synapse-specific enhancement of early LTP through D1/D5 receptors and cAMP.

MeSH Terms
Animals Catecholamines/deficiency Colforsin/metabolism Dopamine Agonists/pharmacology Dopamine Antagonists/pharmacology Hippocampus/physiology Long-Term Potentiation/drug effects Rats Rats, Inbred Strains Receptors, Dopamine D1/physiology Receptors, Dopamine D5 Synapses/physiology
Chemicals
Catecholamines Dopamine Agonists Dopamine Antagonists Drd5 protein, rat Receptors, Dopamine D1 Receptors, Dopamine D5 Colforsin
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Otmakhova N A
Department of Biology and Volen Center for Complex Systems, Brandeis University, Waltham, Massachusetts 02254, USA.
Lisman J E
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1996-12-01
Pages
7478-86
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6579102
Subset
IM
Grants
NINDS NIH HHS · R01 NS027337 · United States
NINDS NIH HHS · 5 R01 NS27337-7 · United States
External Links
PubMed source PMC Full Text View journal details
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