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PMID: 8939672 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

The spindle assembly checkpoint.

Current opinion in cell biology ·Vol. 8 ·No. 6 ·1996-12-00 ·Pages 773-80

Rudner AD, Murray AW

Abstract

The spindle assembly checkpoint monitors proper chromosome attachment to spindle microtubules and is conserved from yeast to humans. Checkpoint components reside on kinetochores of chromosomes and show changes in phosphorylation and localization as cells proceed through mitosis. Adaptation to prolonged checkpoint arrest can occur by inhibitory phosphorylation of Cdc2.

MeSH Terms
Cell Division/physiology Cells/chemistry,cytology,enzymology Spindle Apparatus/chemistry,enzymology
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Rudner A D
Department of Physiology, Box 0444, University of California at San Francisco, 513 Parnassus Avenue, San Francisco, CA 94143-0444, USA. [email protected]
Murray A W
Article Info
Journal
Current opinion in cell biology
Abbr.
Curr Opin Cell Biol
ISSN
0955-0674
DOI
10.1016/s0955-0674(96)80077-9
Email
[email protected]
Published
1996-12-00
Pages
773-80
Language
English
Region
England
NLM ID
8913428
Subset
IM
External Links
PubMed source DOI: 10.1016/s0955-0674(96)80077-9 View journal details
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