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PMID: 8945591 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Effect of in vitro infection of human monocytes with low numbers of Mycobacterium tuberculosis bacteria on monocyte apoptosis.

Infection and immunity ·Vol. 64 ·No. 12 ·1996-12-00 ·Pages 5384-9

Dürrbaum-Landmann I, Gercken J, Flad HD, Ernst M

Abstract

The effect of Mycobacterium tuberculosis H37Rv on spontaneous apoptosis of human monocytes from healthy donors in vitro was investigated. Infection with low numbers of viable M. tuberculosis bacteria prevented spontaneously occurring apoptosis in monocytes. Our data suggest that apoptosis of monocytes appears to be negatively associated with the presence of tumor necrosis factor alpha.

MeSH Terms
Apoptosis/drug effects Cells, Cultured Flow Cytometry Humans Monocytes/microbiology,pathology Mycobacterium tuberculosis Tuberculosis/pathology Tumor Necrosis Factor-alpha/pharmacology
Chemicals
Tumor Necrosis Factor-alpha
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Dürrbaum-Landmann I
Department of Immunology and Cell Biology, Forschungszentrum Borstel, Germany.
Gercken J
Flad H D
Ernst M
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Article Info
Journal
Infection and immunity
Abbr.
Infect Immun
ISSN
0019-9567
DOI
10.1128/iai.64.12.5384-5389.1996
Published
1996-12-00
Pages
5384-9
Language
English
Region
United States
NLM ID
0246127
PMCID
PMC174533
Subset
IM
External Links
PubMed source DOI: 10.1128/iai.64.12.5384-5389.1996 PMC Full Text View journal details
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