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PMID: 8951372 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Sequence and evolution of the human germline V lambda repertoire.

Journal of molecular biology ·Vol. 264 ·No. 2 ·1996-11-29 ·Pages 220-32

Williams SC, Frippiat JP, Tomlinson IM, Ignatovich O, Lefranc MP, Winter G

Abstract

We recently completed a map of the human immunoglobulin lambda (IGL) locus on chromosome 22q11.2 and showed that the V lambda genes are arranged in three distinct clusters, each containing members of different V lambda families. We have now sequenced each of these V lambda genes and determined which are functional by comparison with the expressed repertoire. Our analysis indicates that there are approximately 30 functional V lambda genes, depending on the haplotype, that belong to ten V lambda families (five V lambda 1, five V lambda 2, eight V lambda 3, three V lambda 4, three V lambda 5, one V lambda 6, two V lambda 7, one V lambda 8, one V lambda 9 and one V lambda 10). V lambda genes related to the major human V lambda families (V lambda 1, V lambda 2 and V lambda 3) predominate in species that express mainly lambda light chains.

MeSH Terms
Amino Acid Sequence Base Sequence DNA Evolution, Molecular Germ Cells Humans Immunoglobulin Variable Region/classification,genetics Immunoglobulin lambda-Chains/classification,genetics Molecular Sequence Data Phylogeny Sequence Homology, Amino Acid Sequence Homology, Nucleic Acid
Chemicals
Immunoglobulin Variable Region Immunoglobulin lambda-Chains DNA
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Williams S C
MRC Centre for Protein Engineering Hills Road, Cambridge, UK.
Frippiat J P
Tomlinson I M
Ignatovich O
Lefranc M P
Winter G
Article Info
Journal
Journal of molecular biology
Abbr.
J Mol Biol
ISSN
0022-2836
DOI
10.1006/jmbi.1996.0636
Published
1996-11-29
Pages
220-32
Language
English
Region
England
NLM ID
2985088R
Subset
IM
Databases
GENBANK
X97462, X97463, X97464, X97465, X97466, X97467, X97468, X97469, X97470, X97471, X97472, X97473, X97474, Z73641, Z73642, Z73643, Z73644, Z73645, Z73646, Z73647, Z73648, Z73649, Z73650, Z73651, Z73652, Z73653, Z73654, Z73655, Z73656, Z73657
External Links
PubMed source DOI: 10.1006/jmbi.1996.0636 View journal details
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