The N-terminal alternately spliced regions of PDE4A cAMP-specific phosphodiesterases determine intracellular targeting and regulation of catalytic activity.

3',5'-Cyclic-AMP Phosphodiesterases 3',5'-Cyclic-GMP Phosphodiesterases Alternative Splicing Animals Cyclic Nucleotide Phosphodiesterases, Type 4 Cyclic Nucleotide Phosphodiesterases, Type 6 Enzyme Activation Eye Proteins/metabolism Kinetics Phosphoric Diester Hydrolases/metabolism Rats Signal Transduction Structure-Activity Relationship src Homology Domains

Eye Proteins Phosphoric Diester Hydrolases 3',5'-Cyclic-AMP Phosphodiesterases Cyclic Nucleotide Phosphodiesterases, Type 4 3',5'-Cyclic-GMP Phosphodiesterases Cyclic Nucleotide Phosphodiesterases, Type 6