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PMID: 8987769 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Anatomic organization of the basilar pontine projections from prefrontal cortices in rhesus monkey.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 17 ·No. 1 ·1997-01-01 ·Pages 438-58

Schmahmann JD, Pandya DN

Abstract

In our ongoing attempt to determine the anatomic substrates that could support a cerebellar contribution to cognitive processing, we investigated the prefrontal cortical projections to the basilar pons. A detailed understanding of these pathways is needed, because the prefrontal cortex is critical for a number of complex cognitive operations, and the corticopontine projection is the obligatory first step in the corticopontocerebellar circuit. Prefrontopontine connections were studied using the autoradiographic technique in rhesus monkey. The pontine projections were most prominent and occupied the greatest rostrocaudal extent of the pons when derived from the dorsolateral prefrontal convexity, including areas 8Ad, 9/46d, and 10. Lesser pontine projections were observed from the medial prefrontal convexity and area 45B in the inferior limb of the arcuate sulcus. In contrast, ventral prefrontal and orbitofrontal cortices did not demonstrate pontine projections. The prefrontopontine terminations were located preferentially in the paramedian nucleus and in the medial parts of the peripeduncular nucleus, but each cortical area appeared to have a unique complement of pontine nuclei with which it is connected. The existence of these corticopontine pathways from prefrontal areas concerned with multiple domains of higher-order processing is consistent with the hypothesis that the cerebellum is an essential node in the distributed corticosubcortical neural circuits subserving cognitive operations.

MeSH Terms
Animals Autoradiography Brain Mapping Macaca mulatta/anatomy & histology,physiology Neural Pathways/anatomy & histology Pons/anatomy & histology,physiology Prefrontal Cortex/physiology Synaptic Transmission
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Schmahmann J D
Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, Massachusetts 02114, USA.
Pandya D N
References (72)
72 references, click to expand
  1. An autoradiographic analysis of the efferent connections from premotor and adjacent prefrontal regions (areas 6 and 9) in macaca fascicularis.
    Brain Behav Evol. 1978;15(3):185-234 PMID: 99205
  2. Cerebellar projections to limbic system.
    J Neurophysiol. 1959 Jul;22(4):451-7 PMID: 13673296
  3. The frontal lobe system: cortical-subcortical interrelationships.
    Acta Neurobiol Exp (Wars). 1972;32(2):439-60 PMID: 4627619
  4. Topographical organization of ascending cerebellar projections from the dentate and interposed nuclei in Macaca mulatta: an anterograde degeneration study.
    J Comp Neurol. 1980 Apr 15;190(4):699-731 PMID: 6772694
  5. Pontine projection from striate and prestriate visual cortex in the macaque monkey: an anterograde study.
    Vis Neurosci. 1990 Mar;4(3):205-16 PMID: 2078502
  6. Cortical afferent input to the principalis region of the rhesus monkey.
    Neuroscience. 1985 Jul;15(3):619-37 PMID: 4069349
  7. A cortical network for directed attention and unilateral neglect.
    Ann Neurol. 1981 Oct;10(4):309-25 PMID: 7032417
  8. Prefrontostriatal connections in relation to cortical architectonic organization in rhesus monkeys.
    J Comp Neurol. 1991 Oct 1;312(1):43-67 PMID: 1744243
  9. Primate supplementary eye field: I. Comparative aspects of mesencephalic and pontine connections.
    J Comp Neurol. 1990 Nov 22;301(4):618-42 PMID: 2273101
  10. Cortical projections to the paramedian tegmental and basilar pons in the monkey.
    J Comp Neurol. 1984 Sep 20;228(3):388-408 PMID: 6480918
  11. Regional cerebral blood flow abnormalities in depressed patients with cognitive impairment.
    J Neurol Neurosurg Psychiatry. 1992 Sep;55(9):768-73 PMID: 1402966
  12. Movement and thought: identical control mechanisms by the cerebellum.
    Trends Neurosci. 1993 Nov;16(11):448-50; discussion 453-4 PMID: 7507615
  13. Cortical projections to the red nucleus and the brain stem in the Rhesus monkey.
    Brain Res. 1967 Mar;4(2):151-88 PMID: 4961812
  14. An anatomical investigation of the corticopontaine projection in the primate (Macaca fascicularis and Saimiri sciureus)--II. The projection from frontal and parental association areas.
    Neuroscience. 1979;4(6):747-65 PMID: 113692
  15. Corticopontine projection in the macaque: the distribution of labelled cortical cells after large injections of horseradish peroxidase in the pontine nuclei.
    J Comp Neurol. 1985 May 15;235(3):343-59 PMID: 3998215
  16. Nonmotor functions of the cerebellum.
    Psychol Bull. 1978 Sep;85(5):944-67 PMID: 704722
  17. Frontal eye field efferents in the macaque monkey: II. Topography of terminal fields in midbrain and pons.
    J Comp Neurol. 1988 May 22;271(4):493-506 PMID: 2454971
  18. Visual topography of area TEO in the macaque.
    J Comp Neurol. 1991 Apr 22;306(4):554-75 PMID: 1712794
  19. From movement to thought: anatomic substrates of the cerebellar contribution to cognitive processing.
    Hum Brain Mapp. 1996;4(3):174-98 PMID: 20408197
  20. The cerebellum contributes to linguistic production: a case of agrammatic speech following a right cerebellar lesion.
    Neurology. 1994 Nov;44(11):2047-50 PMID: 7969957
  21. Some novel concepts of cerebellar physiology.
    Mt Sinai J Med. 1974 Jan-Feb;41(1):103-19 PMID: 4592824
  22. Anatomic connections of the fastigial nucleus to the rostral forebrain in the cat.
    Exp Neurol. 1973 Mar-Apr;39(2):285-92 PMID: 4573973
  23. Extracortical connections of the primate frontal cerebral cortex; corticifugal connections.
    J Comp Neurol. 1947 Apr;86(2):119-66 PMID: 20293583
  24. Anatomical investigation of projections to the basis pontis from posterior parietal association cortices in rhesus monkey.
    J Comp Neurol. 1989 Nov 1;289(1):53-73 PMID: 2478597
  25. Architecture and intrinsic connections of the prefrontal cortex in the rhesus monkey.
    J Comp Neurol. 1989 Aug 15;286(3):353-75 PMID: 2768563
  26. Corticofugal connections of area 8 (frontal eye field) in Macaca mulatta.
    Brain Res. 1971 Oct 29;33(2):241-56 PMID: 5002631
  27. Cognitive and language functions of the human cerebellum.
    Trends Neurosci. 1993 Nov;16(11):444-7 PMID: 7507614
  28. Cognitive planning deficit in patients with cerebellar atrophy.
    Neurology. 1992 Aug;42(8):1493-6 PMID: 1641142
  29. Modulation of emotion with a brain pacemamer. Treatment for intractable psychiatric illness.
    J Nerv Ment Dis. 1977 Nov;165(5):300-17 PMID: 303280
  30. Recent contributions to the anatomy and physiology of the cerebellum.
    Arch Neurol Psychiatry. 1950 Aug;64(2):196-219 PMID: 15433637
  31. Activation of a cerebellar output nucleus during cognitive processing.
    Science. 1994 Aug 12;265(5174):949-51 PMID: 8052851
  32. Prefrontal cortex in relation to other cortical areas in rhesus monkey: architecture and connections.
    Prog Brain Res. 1990;85:63-94 PMID: 2094916
  33. The autoradiographic demonstration of axonal connections in the central nervous system.
    Brain Res. 1972 Feb 11;37(1):21-51 PMID: 4110604
  34. Fiber pathways of cortical areas mediating smooth pursuit eye movements in monkeys.
    Ann Neurol. 1988 Feb;23(2):174-83 PMID: 3288083
  35. Demonstration of topographically organized projections from the hypothalamus to the pontine nuclei: an experimental anatomical study in the cat.
    J Comp Neurol. 1988 Feb 15;268(3):313-28 PMID: 3360991
  36. Impairments on nonspatial self-ordered and externally ordered working memory tasks after lesions of the mid-dorsal part of the lateral frontal cortex in the monkey.
    J Neurosci. 1995 Jan;15(1 Pt 1):359-75 PMID: 7823141
  37. Topography of cognition: parallel distributed networks in primate association cortex.
    Annu Rev Neurosci. 1988;11:137-56 PMID: 3284439
  38. The projection of the cerebral cortex on the pons and cerebellum in the macaque monkey.
    J Anat. 1940 Jan;74(Pt 2):201-226.1 PMID: 17104808
  39. Predatory attack, grooming, and consummatory behaviors evoked by electrical stimulation of cat cerebellar nuclei.
    Science. 1973 Nov 23;182(4114):845-7 PMID: 4795751
  40. Severe disturbance of higher cognition after bilateral frontal lobe ablation: patient EVR.
    Neurology. 1985 Dec;35(12):1731-41 PMID: 4069365
  41. The cortical projection to the nucleus reticularis tegmenti pontis in the rhesus monkey.
    Exp Brain Res. 1980;38(1):19-27 PMID: 6766108
  42. The corticopontine projection in the rhesus monkey. Origin and principles of organization.
    Brain. 1978 Jun;101(2):251-83 PMID: 96910
  43. Prefrontal cortex projections to the basilar pons in rhesus monkey: implications for the cerebellar contribution to higher function.
    Neurosci Lett. 1995 Oct 27;199(3):175-8 PMID: 8577391
  44. Corticopontine visual projections in macaque monkeys.
    J Comp Neurol. 1980 Mar 15;190(2):209-29 PMID: 7381057
  45. Visual recognition impairment follows ventromedial but not dorsolateral prefrontal lesions in monkeys.
    Behav Brain Res. 1986 Jun;20(3):249-61 PMID: 3741586
  46. Use of implicit motor imagery for visual shape discrimination as revealed by PET.
    Nature. 1995 May 4;375(6526):54-8 PMID: 7723842
  47. Cortico-striate projections in the rhesus monkey: the organization of certain cortico-caudate connections.
    Brain Res. 1978 Jan 6;139(1):43-63 PMID: 413609
  48. Different patterns of corticopontine projections from separate cortical fields within the inferior parietal lobule and dorsal prelunate gyrus of the macaque.
    Exp Brain Res. 1986;63(2):265-78 PMID: 3530793
  49. Perseverative interference in monkeys following selective lesions of the inferior prefrontal convexity.
    Exp Brain Res. 1970 Nov 26;11(4):376-86 PMID: 4993199
  50. Efferent connections of cortical, area 8 (frontal eye field) in Macaca fascicularis. A reinvestigation using the autoradiographic technique.
    J Comp Neurol. 1977 May 1;173(1):147-64 PMID: 403205
  51. SUBCORTICAL PROJECTIONS OF THE PREFRONTAL LOBE OF THE MONKEY.
    J Comp Neurol. 1964 Dec;123:413-23 PMID: 14245925
  52. Prelunate, occipitotemporal, and parahippocampal projections to the basis pontis in rhesus monkey.
    J Comp Neurol. 1993 Nov 1;337(1):94-112 PMID: 8276995
  53. Role of the cerebellum in complex human behavior.
    Ital J Neurol Sci. 1989 Jun;10(3):291-300 PMID: 2767936
  54. Localization of cognitive operations in the human brain.
    Science. 1988 Jun 17;240(4859):1627-31 PMID: 3289116
  55. Anatomical investigation of projections from thalamus to posterior parietal cortex in the rhesus monkey: a WGA-HRP and fluorescent tracer study.
    J Comp Neurol. 1990 May 8;295(2):299-326 PMID: 1694186
  56. An emerging concept. The cerebellar contribution to higher function.
    Arch Neurol. 1991 Nov;48(11):1178-87 PMID: 1953406
  57. Positron emission tomographic studies of the processing of singe words.
    J Cogn Neurosci. 1989 Spring;1(2):153-70 PMID: 23968463
  58. Does the cerebellum contribute to mental skills?
    Behav Neurosci. 1986 Aug;100(4):443-54 PMID: 3741598
  59. Motor imagery activates the cerebellum regionally. A SPECT rCBF study with 99mTc-HMPAO.
    Brain Res Cogn Brain Res. 1993 Apr;1(2):94-9 PMID: 8513244
  60. Cerebellar contributions to the Papez circuit.
    J Neurosci Res. 1976;2(2):133-46 PMID: 950678
  61. Projections to the basis pontis from the superior temporal sulcus and superior temporal region in the rhesus monkey.
    J Comp Neurol. 1991 Jun 8;308(2):224-48 PMID: 1716269
  62. Impaired non-motor learning and error detection associated with cerebellar damage. A single case study.
    Brain. 1992 Feb;115 Pt 1:155-78 PMID: 1559151
  63. Motor sequence learning: a study with positron emission tomography.
    J Neurosci. 1994 Jun;14(6):3775-90 PMID: 8207487
  64. Corticopontine projections from the cingulate cortex in the rhesus monkey.
    Brain Res. 1981 Feb 2;205(2):391-5 PMID: 7470872
  65. Organization of the thalamo-cortical connexions to the frontal lobe in the rhesus monkey.
    Exp Brain Res. 1977 Sep 28;29(3-4):299-322 PMID: 410652
  66. The efferent projections of the medial prefrontal cortex in the squirrel monkey (Saimiri sciureus).
    Brain Res. 1976 Jun 18;109(3):455-72 PMID: 819102
  67. Highly restricted origin of prefrontal cortical inputs to striosomes in the macaque monkey.
    J Neurosci. 1995 Sep;15(9):5999-6013 PMID: 7666184
  68. Corticopontine projections from the visual area of the superior temporal sulcus in the macaque monkey.
    Arch Ital Biol. 1982 Sep;120(4):411-7 PMID: 7149882
  69. Posterior parietal cortex in rhesus monkey: I. Parcellation of areas based on distinctive limbic and sensory corticocortical connections.
    J Comp Neurol. 1989 Sep 22;287(4):393-421 PMID: 2477405
  70. Anatomical evidence for cerebellar and basal ganglia involvement in higher cognitive function.
    Science. 1994 Oct 21;266(5184):458-61 PMID: 7939688
  71. Projection of precentral, premotor and prefrontal cortex to the basilar pontine grey and to nucleus reticularis tegmenti pontis in the monkey (Macaca fascicularis).
    Schweiz Arch Neurol Neurochir Psychiatr. 1981;129(2):189-208 PMID: 7323772
  72. Projection of the cerebellar dentate nucleus onto the frontal association cortex in monkeys.
    Exp Brain Res. 1979 Sep;37(1):193-8 PMID: 114403
Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1997-01-01
Pages
438-58
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6793685
Subset
IM
Grants
PHS HHS · 16841 · United States
External Links
PubMed source PMC Full Text View journal details
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