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PMID: 8989321 Published · ppublish English Letter Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Projection structure of a gap junction membrane channel at 7 A resolution.

Nature structural biology ·Vol. 4 ·No. 1 ·1997-01-00 ·Pages 39-43

Unger VM, Kumar NM, Gilula NB, Yeager M

Abstract

Electron cryo-microscopy and image analysis of frozen-hydrated, two-dimensional crystals of gap junction membrane channels formed by recombinant alpha 1 connexin (Cx43) reveal a ring of transmembrane alpha-helices that lines the aqueous pore and a second ring of alpha-helices in close contact with the membrane lipids.

MeSH Terms

Animals Cell Line Connexin 43/chemistry,metabolism Cricetinae Crystallography, X-Ray Membrane Lipids/metabolism Microscopy, Electron/methods Recombinant Proteins/chemistry,metabolism

Chemicals

Connexin 43 Membrane Lipids Recombinant Proteins

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Unger V M

Kumar N M

Gilula N B

Yeager M

Article Info

Journal

Nature structural biology

Abbr.

Nat Struct Biol

ISSN

1072-8368

DOI

10.1038/nsb0197-39

Published

1997-01-00

Pages

39-43

Language

English

Region

United States

NLM ID

9421566

Subset

External Links

PubMed source DOI: 10.1038/nsb0197-39

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Projection structure of a gap junction membrane channel at 7 A resolution.

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