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PMID: 8990152 Published · ppublish English Journal Article Review Comment

Sunlight and skin cancer: another link revealed.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 1 ·1997-01-07 ·Pages 11-4

Kraemer KH

Abstract

暂无摘要

MeSH Terms
Age Factors DNA Repair Eicosanoids/metabolism Genes, p53 Humans Immunosuppression Therapy Membrane Proteins/genetics Patched Receptors Receptors, Cell Surface Skin Neoplasms/etiology,genetics,immunology Sunlight/adverse effects
Chemicals
Eicosanoids Membrane Proteins Patched Receptors Receptors, Cell Surface
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Kraemer K H
Laboratory of Molecular Carcinogenesis, National Cancer Institute, Bethesda, MD 20892, USA. [email protected]
References (48)
48 references, click to expand
  1. p53 gene mutations in human skin cancers and precancerous lesions: comparison with immunohistochemical analysis.
    J Invest Dermatol. 1994 Apr;102(4):440-4 PMID: 8151121
  2. Human epidermal cancer and accompanying precursors have identical p53 mutations different from p53 mutations in adjacent areas of clonally expanded non-neoplastic keratinocytes.
    Oncogene. 1996 Feb 15;12(4):765-73 PMID: 8632898
  3. U.v.-induced nuclear accumulation of p53 is evoked through DNA damage of actively transcribed genes independent of the cell cycle.
    Oncogene. 1994 Oct;9(10):2775-84 PMID: 8084582
  4. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis.
    J Invest Dermatol. 1994 Nov;103(5 Suppl):90S-95S PMID: 7963691
  5. Sunburn and p53 in the onset of skin cancer.
    Nature. 1994 Dec 22-29;372(6508):773-6 PMID: 7997263
  6. Specific UV-induced mutation spectrum in the p53 gene of skin tumors from DNA-repair-deficient xeroderma pigmentosum patients.
    Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10529-33 PMID: 8248141
  7. Antioncogenes and human cancer.
    Proc Natl Acad Sci U S A. 1993 Dec 1;90(23):10914-21 PMID: 7902574
  8. Progression of basal cell carcinoma through loss of chromosome 9q and inactivation of a single p53 allele.
    Cancer Res. 1994 Jan 1;54(1):25-7 PMID: 8261448
  9. UV and skin cancer: specific p53 gene mutation in normal skin as a biologically relevant exposure measurement.
    Proc Natl Acad Sci U S A. 1994 Jan 4;91(1):360-4 PMID: 8278394
  10. Non-melanoma skin cancer in renal transplant recipients: the extent of the problem and a strategy for management.
    Br J Plast Surg. 1994 Mar;47(2):86-9 PMID: 8149064
  11. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm.
    Arch Dermatol. 1994 Aug;130(8):1018-21 PMID: 8053698
  12. Delineation of two distinct deleted regions on chromosome 9 in human non-melanoma skin cancers.
    Genes Chromosomes Cancer. 1994 Dec;11(4):222-5 PMID: 7533525
  13. Germ-line p53 mutations in 15 families with Li-Fraumeni syndrome.
    Am J Hum Genet. 1995 Mar;56(3):608-15 PMID: 7887414
  14. Mammalian DNA nucleotide excision repair reconstituted with purified protein components.
    Cell. 1995 Mar 24;80(6):859-68 PMID: 7697716
  15. Nucleotide excision repair syndromes: molecular basis and clinical symptoms.
    Philos Trans R Soc Lond B Biol Sci. 1995 Jan 30;347(1319):75-81 PMID: 7746858
  16. Expression of a transfected DNA repair gene (XPA) in xeroderma pigmentosum group A cells restores normal DNA repair and mutagenesis of UV-treated plasmids.
    Carcinogenesis. 1995 Jul;16(7):1557-63 PMID: 7614689
  17. High susceptibility to ultraviolet-induced carcinogenesis in mice lacking XPC.
    Nature. 1995 Sep 14;377(6545):162-5 PMID: 7675084
  18. High incidence of ultraviolet-B-or chemical-carcinogen-induced skin tumours in mice lacking the xeroderma pigmentosum group A gene.
    Nature. 1995 Sep 14;377(6545):165-8 PMID: 7675085
  19. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA.
    Nature. 1995 Sep 14;377(6545):169-73 PMID: 7675086
  20. Early p53 alterations in mouse skin carcinogenesis by UVB radiation: immunohistochemical detection of mutant p53 protein in clusters of preneoplastic epidermal cells.
    Proc Natl Acad Sci U S A. 1996 Jan 9;93(1):274-8 PMID: 8552621
  21. Cancer statistics, 1996.
    CA Cancer J Clin. 1996 Jan-Feb;46(1):5-27 PMID: 8548526
  22. Molecular basis of sun-induced premature skin ageing and retinoid antagonism.
    Nature. 1996 Jan 25;379(6563):335-9 PMID: 8552187
  23. p53 gene mutation: software and database.
    Nucleic Acids Res. 1996 Jan 1;24(1):147-50 PMID: 8594565
  24. DNA repair and cytokines in antimutagenesis and anticarcinogenesis.
    Mutat Res. 1996 Feb 19;350(1):255-60 PMID: 8657189
  25. Ultraviolet-specific mutations in p53 gene in skin tumors in xeroderma pigmentosum patients.
    Cancer Res. 1993 Jul 1;53(13):2944-6 PMID: 8319200
  26. Human homolog of patched, a candidate gene for the basal cell nevus syndrome.
    Science. 1996 Jun 14;272(5268):1668-71 PMID: 8658145
  27. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome.
    Cell. 1996 Jun 14;85(6):841-51 PMID: 8681379
  28. Genetic change in actinic keratoses.
    Oncogene. 1996 Jun 20;12(12):2483-90 PMID: 8700506
  29. Differential allele loss on chromosome 9q22.3 in human non-melanoma skin cancer.
    Br J Cancer. 1996 Jul;74(2):246-50 PMID: 8688329
  30. Enhanced inflammation and immunosuppression by ultraviolet radiation in xeroderma pigmentosum group A (XPA) model mice.
    J Invest Dermatol. 1996 Sep;107(3):343-8 PMID: 8751968
  31. Blockage of RNA polymerase as a possible trigger for u.v. light-induced apoptosis.
    Oncogene. 1996 Aug 15;13(4):823-31 PMID: 8761304
  32. p53 tumor suppressor gene: at the crossroads of molecular carcinogenesis, molecular epidemiology, and cancer risk assessment.
    Environ Health Perspect. 1996 May;104 Suppl 3:435-9 PMID: 8781359
  33. The role of the human homologue of Drosophila patched in sporadic basal cell carcinomas.
    Nat Genet. 1996 Sep;14(1):78-81 PMID: 8782823
  34. DNA repair in humans.
    Annu Rev Genet. 1995;29:69-105 PMID: 8825469
  35. The effect of donor age on the processing of UV-damaged DNA by cultured human cells: reduced DNA repair capacity and increased DNA mutability.
    Mutat Res. 1996 Oct 18;364(2):117-23 PMID: 8879277
  36. Frequent clones of p53-mutated keratinocytes in normal human skin.
    Proc Natl Acad Sci U S A. 1996 Nov 26;93(24):14025-9 PMID: 8943054
  37. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion.
    J Investig Dermatol Symp Proc. 1996 Apr;1(2):136-42 PMID: 9627707
  38. DNA repair protects against cutaneous and internal neoplasia: evidence from xeroderma pigmentosum.
    Carcinogenesis. 1984 Apr;5(4):511-4 PMID: 6705149
  39. Nevoid basal-cell carcinoma syndrome.
    Medicine (Baltimore). 1987 Mar;66(2):98-113 PMID: 3547011
  40. Malignant transformation of solar keratoses to squamous cell carcinoma.
    Lancet. 1988 Apr 9;1(8589):795-7 PMID: 2895318
  41. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma.
    Proc Natl Acad Sci U S A. 1991 Nov 15;88(22):10124-8 PMID: 1946433
  42. Immunological effects of ultraviolet radiation.
    J Dermatol. 1991 Aug;18(8):429-33 PMID: 1761789
  43. p53 mutations in basal cell carcinomas.
    Cancer Res. 1992 Jul 1;52(13):3804-6 PMID: 1617650
  44. DNA repair and aging in basal cell carcinoma: a molecular epidemiology study.
    Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1614-8 PMID: 8434025
  45. p53 gene mutations in human epithelial skin cancers.
    Oncogene. 1993 Mar;8(3):583-8 PMID: 8437842
  46. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers.
    Proc Natl Acad Sci U S A. 1993 May 1;90(9):4216-20 PMID: 8483937
  47. p53 mutations are common and early events that precede tumor invasion in squamous cell neoplasia of the skin.
    J Invest Dermatol. 1993 Jun;100(6):746-8 PMID: 8496613
  48. Multiple self-healing squamous epitheliomata (ESS1) mapped to chromosome 9q22-q31 in families with common ancestry.
    Nat Genet. 1993 Feb;3(2):165-9 PMID: 8499949
Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.1.11
Email
[email protected]
Published
1997-01-07
Pages
11-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33651
Subset
IM
Grants
Intramural NIH HHS · Z01 BC004517-31 · United States
Corrections
CommentOn
PMID: 8943054
External Links
PubMed source DOI: 10.1073/pnas.94.1.11 PMC Full Text View journal details
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