The etiology and pathogenesis of laryngeal carcinoma.

Otolaryngologic clinics of North America ·Vol. 30 ·No. 1 ·1997-02-00 ·Pages 1-19

Koufman JA, Burke AJ

Abstract

Epidemiologic data suggest that the etiology and pathogenesis of laryngeal carcinoma are influenced by environmental and lifestyle-related factors, such as tobacco use, ethanol consumption, and exposure to toxic substances. In addition, dietary factors, irradiation, papilloma virus infection, and laryngopharyngeal reflux seem to be significant carcinogenic cofactors. This article presents a multi-factorial model of laryngeal mucosal carcinogenesis.

MeSH Terms

Alcohol Drinking/adverse effects Carcinoma, Squamous Cell/epidemiology,etiology Cocarcinogenesis Environment Ethanol/adverse effects Feeding Behavior Female Gastroesophageal Reflux/complications Humans Laryngeal Diseases/etiology Laryngeal Neoplasms/epidemiology,etiology Life Style Male Neoplasms, Radiation-Induced/epidemiology,etiology Papillomaviridae Papillomavirus Infections Pharyngeal Diseases/etiology Radiation Effects Risk Factors Smoking/adverse effects Toxins, Biological/adverse effects Tumor Virus Infections

Chemicals

Toxins, Biological Ethanol

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Koufman J A

Center For Voice Disorders of Wake Forest University, Department of Otolaryngology, Bowman Gray School of Medicine, Winston-Salem, North Carolina 27157-1034, USA.

Burke A J

Article Info

Journal

Otolaryngologic clinics of North America

Abbr.

Otolaryngol Clin North Am

ISSN

0030-6665

Published

1997-02-00

Pages

1-19

Language

English

Region

United States

NLM ID

0144042

Subset

External Links

PubMed source View journal details

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The etiology and pathogenesis of laryngeal carcinoma.

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