Home LiteratureArticle Details
PMID: 9000751 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S.

Replication slippage may cause parallel evolution in the secondary structures of mitochondrial transfer RNAs.

Molecular biology and evolution ·Vol. 14 ·No. 1 ·1997-01-00 ·Pages 30-9

Macey JR, Larson A, Ananjeva NB, Papenfuss TJ

Abstract

Presence of the dihydrouridine (D) stem in the mitochondrial cysteine tRNA is unusually variable among lepidosaurian reptiles. Phylogenetic and comparative analyses of cysteine tRNA gene sequences identify eight parallel losses of the D-stem, resulting in D-arm replacement loops. Sampling within the monophyletic Acrodonta provides no evidence for reversal. Slipped-strand mispairing of noncontiguous repeated sequences during replication or direct replication slippage can explain repeats observed within cysteine tRNAs that contain a D-arm replacement loop. These two mechanisms involving replication slippage can account for the loss of the cysteine tRNA D-stem in several lepidosaurian lineages, and may represent general mechanisms by which the secondary structures of mitochondrial tRNAs are altered.

MeSH Terms
Animals Base Sequence DNA Primers/genetics DNA, Mitochondrial/genetics Evolution, Molecular Molecular Sequence Data Nucleic Acid Conformation Phylogeny RNA/chemistry,genetics RNA, Mitochondrial RNA, Transfer, Cys/chemistry,genetics Repetitive Sequences, Nucleic Acid Reptiles/classification,genetics Sequence Deletion Sequence Homology, Nucleic Acid
Chemicals
DNA Primers DNA, Mitochondrial RNA, Mitochondrial RNA, Transfer, Cys RNA
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Macey J R
Department of Biology, Washington University, St. Louis, Missouri 63130, USA.
Larson A
Ananjeva N B
Papenfuss T J
Article Info
Journal
Molecular biology and evolution
Abbr.
Mol Biol Evol
ISSN
0737-4038
DOI
10.1093/oxfordjournals.molbev.a025699
Published
1997-01-00
Pages
30-9
Language
English
Region
United States
NLM ID
8501455
Subset
IM
Databases
GENBANK
U71325, U71326, U71327, U71328, U71329, U71330, U71331, U71332, U71333, U71334, U71335, U71336, U71337, U71338, U71339, U71340, U71341, U71342, U71343, U71344, U71345, U71346, U71347, U71348, U71349, U71350, U71351, U71352, U71353, U71354
External Links
PubMed source DOI: 10.1093/oxfordjournals.molbev.a025699 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: [email protected]

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2