Colonic mucosal atrophy induced by a liquid elemental diet in rats.

The American journal of digestive diseases ·Vol. 22 ·No. 9 ·1977-09-00 ·Pages 808-12

Janne P, Carpentier Y, Willems G

Abstract

The weight, the total crypt cell population, and the proliferation parameters of the colon were estimated in rats during a 4-week administration of a liquid elemental diet (Vivonex standard). Both mitotic and DNA synthesis activity were decreased (P less than 0.01) in the colonic mucosa during the administration of the diet. The weight of the colon was electively decreased (P less than 0.01) from the first week of the treatment. After four weeks, a 75% decrease in the cell population of mucosal glands was observed. This showed that considerable atrophy of the colonic mucosa occurred under the effect of feeding the elemental diet. This atrophy was probably mediated by a reduction in the proliferative activity of the stem cells in the mucosal glands.

MeSH Terms

Animal Nutritional Physiological Phenomena Animals Atrophy Body Weight Colon/pathology Intestinal Diseases/etiology Intestinal Mucosa/pathology Male Organ Size Rats

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Janne P

Carpentier Y

Willems G

References (28)

28 references, click to expand

Control of deoxyribonucleic acid synthesis in normal rabbit colonic mucosa.
Gastroenterology. 1975 Oct;69(4):951-9 PMID: 170158
Structural and hormonal alterations in the gastrointestinal tract of parenterally fed rats.
Gastroenterology. 1975 May;68(5 Pt 1):1177-83 PMID: 805078
Kinetics of proliferation and migration of epithelial cells in the guinea pig colon.
Exp Cell Res. 1968 Apr;50(1):93-103 PMID: 5650866
The effect of starvation and refeeding on cell population kinetics in the rat small bowel mucosa.
J Anat. 1975 Feb;119(Pt 1):105-21 PMID: 1133081
The effect of low-residue diet on the canine colonic wall.
Ann Chir Gynaecol Fenn. 1971;60(3):132-4 PMID: 5156621
Intestinal adaptation.
N Engl J Med. 1973 Mar 8;288(10):520-1 PMID: 4684185
The effect of a chemically defined diet on the faecal flora and faecal steroid concentration.
Gut. 1973 Oct;14(10):790-3 PMID: 4202272
Proliferation kinetics in epithelium of guinea-pig colon. I. Variations depending on crypt length and its localization.
Cell Tissue Kinet. 1970 Oct;3(4):375-83 PMID: 5523062
Studies in metabolic nutrition employing chemically defined diets. I. Extended feeding of normal human adult males.
Am J Clin Nutr. 1970 May;23(5):525-45 PMID: 5444989
Decreased trypsin and bile acids in ileal fistula drainage during the administration of a chemically defined liquid elemental diet.
Br J Surg. 1976 Feb;63(2):133-6 PMID: 1252713
Action of gastrin on gastrointestinal structure and function.
Gastroenterology. 1975 May;68(5 Pt 1):1184-92 PMID: 805079
Influence of starvation and refeeding on mucosal size and epithelial renewal in the rat small intestine.
Am J Anat. 1972 Apr;133(4):391-400 PMID: 5016502
Effects on small-intestinal function and structure induced by feeding a deconjugated bile salt.
Gut. 1973 Jul;14(7):519-28 PMID: 4269724
Proliferative changes in the colon.
Am J Dig Dis. 1974 Nov;19(11):1029-32 PMID: 4421193
Studies in metabolic nutrition employing chemically defined diets. II. Effects on gut microflora populations.
Am J Clin Nutr. 1970 May;23(5):546-59 PMID: 4986450
Small intestinal mucosal injury in the experimental blind loop syndrome. Light- and electron-microscopic and histochemical studies.
Gastroenterology. 1975 May;68(5 Pt 1):1193-203 PMID: 1126607
The effect of an intraduodenal elemental diet on pancreatic secretion.
Surg Gynecol Obstet. 1975 Feb;140(2):241-5 PMID: 1124475
Depression of antral and serum gastrin concentration by food deprivation in the rat.
Gastroenterology. 1975 Jun;68(6):1473-9 PMID: 1093920
Effect of starvation on the tissue composition of the small intestine in the rat.
Am J Physiol. 1968 Jul;215(1):75-7 PMID: 5659346
Epidermal regeneration after cellophane tape stripping of hairless mouse skin.
Cell Tissue Kinet. 1970 Jul;3(3):243-52 PMID: 5523054
Proliferation kinetics in epithelium of guinea-pig colon. II. Distribution of proliferating and specialized cells along various crypts.
Cell Tissue Kinet. 1971 May;4(3):225-32 PMID: 5126174
Protein, carbohydrate and fat content of the diet of the rat as related to growth.
J Nutr. 1963 Apr;79:395-8 PMID: 13955148
[Autoradiographic measurement of cell proliferation at different levels of the normal and pathologic gastrointestinal tract. Use of biopsies incubated in vitro].
Rev Eur Etud Clin Biol. 1971 Mar;16(3):233-9 PMID: 5555989
Epithelial cell renewal in cultured rectal biopsies in ulcerative colitis.
Gastroenterology. 1973 Mar;64(3):383-90 PMID: 4691587
Renewal of the colonic epithelium of the rat.
Am J Dig Dis. 1960 Oct;5:833-5 PMID: 13769796
Perfusion of the canine colon with unconjugated bile acids. Effect on water and electrolyte transport, morphology, and bile acid absorption.
Gastroenterology. 1970 Jul;59(1):120-9 PMID: 5426982
Role of oral intake in maintenance of gut mass and disaccharide activity.
Gastroenterology. 1974 Nov;67(5):975-82 PMID: 4214726
Cell renewal in the human rectum. In vitro autoradiographic study on active ulcerative colitis.
Gastroenterology. 1970 Jun;58(6):851-5 PMID: 5423896

Article Info

Journal

The American journal of digestive diseases

Abbr.

Am J Dig Dis

ISSN

0002-9211

DOI

10.1007/BF01694512

Published

1977-09-00

Pages

808-12

Language

English

Region

United States

NLM ID

0404011

Subset

External Links

PubMed source DOI: 10.1007/BF01694512

Analysis Services

Colonic mucosal atrophy induced by a liquid elemental diet in rats.

Contact

WeChat Official Account