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PMID: 900921 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Rosamicin in urethral and vaginal secretions and tissues in dogs and rats.

Antimicrobial agents and chemotherapy ·Vol. 12 ·No. 2 ·1977-08-00 ·Pages 237-9

Hoyme U, Baumueller A, Madsen PO

Abstract

In animal studies we investigated the distribution of rosamicin in plasma and urethral and vaginal tissues in rats as well as in urethral and vaginal secretions in dogs. We found concentration ratios between urethral secretion and plasma of 1.9 and between vaginal secretion and plasma of 2.4. The rosamicin concentrations in urethral and vaginal tissue significantly exceeded the levels of all other tissues investigated. Because rosamicin could be valuable for the treatment of bacterial urethritis and the colonization of the vaginal introitus with fecal bacteria in women, it should be investigated clinically in this respect.

MeSH Terms
Aminoglycosides/blood,metabolism Animals Anti-Bacterial Agents/blood,metabolism Dogs Female Male Prostate/metabolism Rats Time Factors Urethra/metabolism Urinary Bladder/metabolism Vagina/metabolism
Chemicals
Aminoglycosides Anti-Bacterial Agents
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Hoyme U
Baumueller A
Madsen P O
References (7)
7 references, click to expand
  1. INTRACAVITARY CIRCULATION OF AQUEOUS MATERIAL IN THE HUMAN VAGINA.
    Acta Obstet Gynecol Scand. 1964;43:360-8 PMID: 14286007
  2. Prostatic antibacterial factor. Identity and significance.
    Urology. 1976 Feb;7(2):169-77 PMID: 54972
  3. Perineal, vaginal and urethral bacteriology of young women. I. Incidence of gram-negative colonization.
    J Urol. 1974 Jan;111(1):88-92 PMID: 4591742
  4. Urethral glands in the wall of the female urethra of rats, mice and closely related rodents.
    Acta Anat (Basel). 1974;90(3):381-7 PMID: 4477438
  5. A new Micromonospora-produced macrolide antibiotic, rosamicin.
    J Antibiot (Tokyo). 1972 Nov;25(11):641-6 PMID: 4647834
  6. The diffusion and concentration of trimethoprim in human vaginal fluid.
    J Infect Dis. 1975 Mar;131(3):261-6 PMID: 1092766
  7. Recurrent urinary infections in adult women. The role of introital enterobacteria.
    Calif Med. 1971 Jul;115(1):1-19 PMID: 5105794
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.12.2.237
Published
1977-08-00
Pages
237-9
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC429891
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.12.2.237 PMC Full Text View journal details
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