Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

Current opinion in genetics & development ·Vol. 7 ·No. 1 ·1997-02-00 ·Pages 93-8

Carr AM

Abstract

The Mec1(sc)/Rad3(sp) protein family is central to the checkpoint pathways of cells. Functions upstream and downstream of Mec1(sc)/Rad3(sp) show both similarities and differences when compared between organisms. Analogy with a related protein, DNAPKcs, suggests that different subunits may activate Mec1(sc)/Rad3(sp) in response to specific DNA or DNA-protein structures.

MeSH Terms

Adenosine Triphosphatases/metabolism Cell Cycle/physiology DNA Helicases/metabolism DNA, Fungal/metabolism Fungal Proteins/metabolism Intracellular Signaling Peptides and Proteins Protein Serine-Threonine Kinases Saccharomyces cerevisiae Proteins

Chemicals

DNA, Fungal Fungal Proteins Intracellular Signaling Peptides and Proteins Saccharomyces cerevisiae Proteins MEC1 protein, S cerevisiae Protein Serine-Threonine Kinases Adenosine Triphosphatases Rad3 protein, S cerevisiae DNA Helicases

Authors & Affiliations

1 authors, click to expand affiliations / ORCID

Carr A M

MRC Cell Mutation Unit, Sussex University, Falmer BN1 9RR UK. a.m. [email protected]

Article Info

Journal

Current opinion in genetics & development

Abbr.

Curr Opin Genet Dev

ISSN

0959-437X

DOI

10.1016/s0959-437x(97)80115-3

[email protected]

Published

1997-02-00

Pages

93-8

Language

English

Region

England

NLM ID

9111375

Subset

External Links

PubMed source DOI: 10.1016/s0959-437x(97)80115-3 View journal details

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Control of cell cycle arrest by the Mec1sc/Rad3sp DNA structure checkpoint pathway.

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