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PMID: 903773 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Critical cerebral blood flow for production of hemiparesis after unilateral carotid occlusion in the gerbil.

Journal of neurology, neurosurgery, and psychiatry ·Vol. 40 ·No. 6 ·1977-06-00 ·Pages 595-9

Nakai K, Welch KM, Meyer JS

Abstract

Transient cerebral ischaemia, produced by temporary unilateral common carotid artery (CCA) occlusion, was studied in the gerbil by means of chronically implanted hydrogen electrodes. Unilateral CCA occlusion produced behavioural signs of neurological deficit only when regional cerebral blood flow values in the ipsilateral cerebral hemisphere fell below a critical range of 0.20-0.22 ml/gm brain/min. Postischaemic poor perfusion (no-reflow) was an infrequent observation after removal of CCA occlusion.

MeSH Terms
Animals Blood Flow Velocity Brain/blood supply Carotid Arteries/physiology Cerebral Cortex/blood supply Constriction Disease Models, Animal Female Functional Laterality Gerbillinae Hemiplegia/etiology Ischemic Attack, Transient/complications,diagnosis Male Regional Blood Flow Time Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Nakai K
Welch K M
Meyer J S
References (10)
10 references, click to expand
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Article Info
Journal
Journal of neurology, neurosurgery, and psychiatry
Abbr.
J Neurol Neurosurg Psychiatry
ISSN
0022-3050
DOI
10.1136/jnnp.40.6.595
Published
1977-06-00
Pages
595-9
Language
English
Region
England
NLM ID
2985191R
PMCID
PMC492767
Subset
IM
External Links
PubMed source DOI: 10.1136/jnnp.40.6.595 PMC Full Text View journal details
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