Molecular mechanisms underlying the actions of the pro-inflammatory cytokine interleukin 1. Royal Irish Academy Medal Lecture.

Animals Cyclic AMP/metabolism GTP-Binding Proteins/physiology Humans Inflammation/immunology,physiopathology Interleukin 1 Receptor Antagonist Protein Interleukin-1/pharmacology,physiology Mammals NF-kappa B/metabolism Phospholipids/metabolism Protein Kinases Receptors, Interleukin-1/antagonists & inhibitors,physiology Receptors, Interleukin-1 Type I Receptors, Interleukin-1 Type II Second Messenger Systems Sialoglycoproteins/physiology Signal Transduction Transcription Factors/metabolism Virulence Factors, Bordetella/pharmacology

IL1RN protein, human Interleukin 1 Receptor Antagonist Protein Interleukin-1 NF-kappa B Phospholipids Receptors, Interleukin-1 Receptors, Interleukin-1 Type I Receptors, Interleukin-1 Type II Sialoglycoproteins Transcription Factors Virulence Factors, Bordetella Cyclic AMP Protein Kinases GTP-Binding Proteins