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PMID: 9064338 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection.

The Journal of experimental medicine ·Vol. 184 ·No. 3 ·1996-09-01 ·Pages 1191-6

Sprenger H, Meyer RG, Kaufmann A, Bussfeld D, Rischkowsky E, Gemsa D

Abstract

It is characteristic for virus infections that monocytes/macrophages and lymphocytes infiltrate infected tissue while neutrophils are absent. To understand the mechanisms selectively attracting mononuclear cells in viral diseases, we examined in an influenza A virus model the expression and regulation of chemokines as candidate molecules responsible for the immigration of leukocytes into inflamed tissue. After influenza A virus infection of human monocytes, a rapid expression of the mononuclear cell attracting CC-chemokine genes MIP-1, MCP-1, and RANTES occurred which was followed by the release of chemokine proteins. In striking contrast to CC-chemokines, the expression of the prototype neutrophil CXC-chemoattractants IL-8 and GRO-alpha was completely suppressed after influenza A infection. The release of other neutrophil chemotactic factors was excluded by microchemotaxis assays. These results suggest that the virus-specific induction of mononuclear cell-attracting chemokines accounts for the preferential influx of mononuclear leukocytes into virus-infected tissue.

MeSH Terms
Chemokine CCL2/metabolism Chemokine CCL4 Chemokine CCL5/metabolism Chemokines/blood Chemotaxis, Leukocyte Humans Influenza, Human/blood Lipopolysaccharides/pharmacology Macrophage Inflammatory Proteins/metabolism Monocytes/virology Neutrophils/virology Orthomyxoviridae
Chemicals
Chemokine CCL2 Chemokine CCL4 Chemokine CCL5 Chemokines Lipopolysaccharides Macrophage Inflammatory Proteins
Authors & Affiliations
6 authors, click to expand affiliations / ORCID
Sprenger H
Institute of Immunology, Philipps-University Marburg, Germany.
Meyer R G
Kaufmann A
Bussfeld D
Rischkowsky E
Gemsa D
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.184.3.1191
Published
1996-09-01
Pages
1191-6
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192790
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.184.3.1191 PMC Full Text View journal details
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