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PMID: 9064350 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Thymic dendritic cell precursors: relationship to the T lymphocyte lineage and phenotype of the dendritic cell progeny.

The Journal of experimental medicine ·Vol. 184 ·No. 3 ·1996-09-01 ·Pages 903-11

Wu L, Li CL, Shortman K

Abstract

Successive T-precursors isolated from adult mouse thymus were examined for their developmental potential, by transfer to irradiated Ly 5-disparate recipients. The earliest, "low CD4" precursors formed T, B, and dendritic cells (DC), but not myeloid cells, in accordance with earlier studies. Surprisingly, the next downstream CD4-8-3 44+25+ precursor population still formed DC as well as T cells although it no longer formed B or myeloid cells. Further down-stream, the CD4-8 3-44-25+ population formed only T cells. The thymic and splenic DC progeny of the early thymic precursors all expressed high levels of CD8 alpha, in contrast with normal splenic DC and the splenic DC progeny of bone marrow stem cells, which consisted of both CD8 and CD8+ DC. A common precursor of T cells and of a subclass of DC is proposed, with CD8 alpha as a marker of the lymphoid-related DC lineage.

MeSH Terms
Animals Antigens, Ly/analysis Dendrites/ultrastructure Mice Mice, Inbred C57BL Phenotype T-Lymphocytes/cytology Thymus Gland/cytology
Chemicals
Antigens, Ly
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Wu L
Walter and Eliza Hall Institute of Medical Research, Melbourne, Victoria, Australia.
Li C L
Shortman K
References (27)
27 references, click to expand
  1. Evidence that the Pgp-1 glycoprotein is expressed on thymus-homing progenitor cells of the thymus.
    Cell Immunol. 1985 Apr 1;91(2):397-403 PMID: 2859928
  2. Early T lymphocyte progenitors.
    Annu Rev Immunol. 1996;14:29-47 PMID: 8717506
  3. A murine early thymocyte developmental sequence is marked by transient expression of the interleukin 2 receptor.
    Proc Natl Acad Sci U S A. 1989 Mar;86(5):1614-8 PMID: 2493646
  4. Molecular cloning of the murine BP-1/6C3 antigen: a member of the zinc-dependent metallopeptidase family.
    Proc Natl Acad Sci U S A. 1990 Feb;87(3):993-7 PMID: 1689065
  5. CD4 expressed on earliest T-lineage precursor cells in the adult murine thymus.
    Nature. 1991 Jan 3;349(6304):71-4 PMID: 1702186
  6. The generation and fate of thymocytes.
    Semin Immunol. 1990 Jan;2(1):3-12 PMID: 2129900
  7. Developmental potential of the earliest precursor cells from the adult mouse thymus.
    J Exp Med. 1991 Dec 1;174(6):1617-27 PMID: 1683894
  8. Rhodamine123 reveals heterogeneity within murine Lin-, Sca-1+ hemopoietic stem cells.
    J Exp Med. 1992 Jun 1;175(6):1443-7 PMID: 1375260
  9. The surface phenotype of dendritic cells purified from mouse thymus and spleen: investigation of the CD8 expression by a subpopulation of dendritic cells.
    J Exp Med. 1992 Jul 1;176(1):47-58 PMID: 1613465
  10. Generation of large numbers of dendritic cells from mouse bone marrow cultures supplemented with granulocyte/macrophage colony-stimulating factor.
    J Exp Med. 1992 Dec 1;176(6):1693-702 PMID: 1460426
  11. Thymic dendritic cells and T cells develop simultaneously in the thymus from a common precursor population.
    Nature. 1993 Apr 22;362(6422):761-3 PMID: 8469288
  12. A developmental pathway involving four phenotypically and functionally distinct subsets of CD3-CD4-CD8- triple-negative adult mouse thymocytes defined by CD44 and CD25 expression.
    J Immunol. 1993 May 15;150(10):4244-52 PMID: 8387091
  13. Characterization of c-kit positive intrathymic stem cells that are restricted to lymphoid differentiation.
    J Exp Med. 1993 Oct 1;178(4):1283-92 PMID: 7690832
  14. Intrathymic lymphoid precursor cells during fetal thymus development.
    J Immunol. 1993 Dec 1;151(11):5887-95 PMID: 8245436
  15. Control points in early T-cell development.
    Immunol Today. 1993 Nov;14(11):547-53 PMID: 7903854
  16. The CD44 expressed on the earliest intrathymic precursor population functions as a thymus homing molecule but does not bind to hyaluronate.
    Immunol Lett. 1993 Sep;38(1):69-75 PMID: 7507884
  17. Identification of pro-thymocytes in murine fetal blood: T lineage commitment can precede thymus colonization.
    EMBO J. 1994 Sep 15;13(18):4229-40 PMID: 7523109
  18. Analysis and expression of a cloned pre-T cell receptor gene.
    Science. 1994 Nov 18;266(5188):1208-12 PMID: 7973703
  19. The development of T and non-T cell lineages from CD34+ human thymic precursors can be traced by the differential expression of CD44.
    J Exp Med. 1995 Feb 1;181(2):475-83 PMID: 7530757
  20. Mouse thymus dendritic cells: kinetics of development and changes in surface markers during maturation.
    Eur J Immunol. 1995 Feb;25(2):418-25 PMID: 7875203
  21. T cell receptor gene recombination patterns and mechanisms: cell death, rescue, and T cell production.
    J Exp Med. 1995 Jul 1;182(1):121-7 PMID: 7790812
  22. Requirement for TNF-alpha and IL-1 alpha in fetal thymocyte commitment and differentiation.
    Science. 1995 Jun 30;268(5219):1906-9 PMID: 7541554
  23. T-cell lineage commitment and cytokine responses of thymic progenitors.
    Blood. 1995 Sep 1;86(5):1850-60 PMID: 7655014
  24. Human T, B, natural killer, and dendritic cells arise from a common bone marrow progenitor cell subset.
    Immunity. 1995 Oct;3(4):459-73 PMID: 7584137
  25. CD4 and CD8 expression and T cell antigen receptor gene rearrangement in early intrathymic precursor cells.
    Eur J Immunol. 1996 Apr;26(4):731-7 PMID: 8625961
  26. A subclass of dendritic cells kills CD4 T cells via Fas/Fas-ligand-induced apoptosis.
    J Exp Med. 1996 Apr 1;183(4):1789-96 PMID: 8666935
  27. Developmental status and reconstitution potential of subpopulations of murine thymocytes.
    Immunol Rev. 1988 Aug;104:81-120 PMID: 3049319
Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.184.3.903
Published
1996-09-01
Pages
903-11
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192802
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.184.3.903 PMC Full Text View journal details
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